本文關(guān)鍵詞： 腦心通膠囊 急性腦梗死 療效 細胞炎癥因子 凝血功能 血液流變學　出處：《中華中醫(yī)藥學刊》2017年06期 　論文類型：期刊論文

【摘要】：目的:探討腦心通膠囊治療急性腦梗死患者療效及對細胞炎癥因子、凝血功能和血液流變學的影響。方法:急性腦梗死患者98例按照隨機數(shù)字表法分為治療組49例與對照組49例。對照組患者采用常規(guī)西醫(yī)治療,治療組在對照組基礎(chǔ)上結(jié)合腦心通膠囊治療。兩組療程均為4周。比較兩組治療療效,治療前后NIHSS評分、細胞炎癥因子、凝血功能和血液流變學水平的影響,及不良反應(yīng)發(fā)生情況。結(jié)果:治療組總有效率(91.84%)高于對照組(73.47%),且有統(tǒng)計學意義(P0.05);治療組治療后NIHSS評分低于對照組(t值=11.681,P0.05);治療組治療后MCP-1和hs-CRP水平低于對照組(t值=18.060、10.528,P0.05);治療組治療后PT、APTT水平水平高于對照組而D-二聚體水平低于對照組(t值=17.054、10.787、10.579,P0.05);治療組治療后血漿黏度、全血黏度高切、全血黏度低切水平低于對照組(t值=6.869、5.754、7.609,P0.05);兩組肝腎功能、心電圖、血常規(guī)均未見異常,且無明顯藥物不良反應(yīng)。結(jié)論:腦心通膠囊治療急性腦梗死患者療效明顯,可降低血清MCP-1和hs-CRP水平,改善患者凝血功能和血液流變學異常,具有重要研究意義。
[Abstract]:Objective: to investigate the therapeutic effect of Naoxintong capsule on acute cerebral infarction patients and to investigate the effect of Naoxintong capsule on inflammatory cytokines. Methods: 98 patients with acute cerebral infarction were randomly divided into treatment group (n = 49) and control group (n = 49). The treatment group was treated with Naoxintong capsule on the basis of the control group. The course of treatment in both groups was 4 weeks. The therapeutic efficacy, NIHSS score and cytokines were compared before and after treatment. Results: the total effective rate of the treatment group (91.84) was higher than that of the control group (73.47). And there was statistical significance (P0.05). The NIHSS score of the treatment group was lower than that of the control group (P < 11.681). After treatment, the levels of MCP-1 and hs-CRP in the treatment group were lower than those in the control group. After treatment, the level of PTT APTT in the treatment group was higher than that in the control group, while the level of D-dimer was lower than that in the control group. The plasma viscosity and whole blood viscosity of the treatment group were high and the low shear level of the whole blood viscosity was lower than that of the control group. Liver and kidney function, electrocardiogram, blood routine were not abnormal, and there was no obvious adverse drug reaction. Conclusion: Naoxintong capsule is effective in treating acute cerebral infarction patients. It is of great significance to reduce serum MCP-1 and hs-CRP levels and improve coagulation function and hemorheology abnormality.
【作者單位】： 紹興文理學院附屬醫(yī)院內(nèi)科;
【分類號】：R743.3
【正文快照】： 腦梗死是常見的一種腦血管疾病,認為其發(fā)生與血管內(nèi)皮損傷、血栓形成、自由基損傷、血小板聚集及血黏度升高等密切相關(guān)[1-2]。近年來急性腦梗死發(fā)病率呈不斷上升趨勢,嚴重影響人們身心健康和生活質(zhì)量[3]。目前,單純采用西醫(yī)治療急性腦梗死患者效果并不十分理想。腦心通膠囊是

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