本文關(guān)鍵詞：少突膠質(zhì)細胞瘤中FABP5的表達及其臨床意義　出處：《臨床與實驗病理學雜志》2016年12期 　論文類型：期刊論文

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【摘要】：目的探討脂肪酸結(jié)合蛋白5(fatty acid-binding protein 5,FABP5)在少突膠質(zhì)細胞瘤中的表達及其臨床意義。方法采用免疫組化En Vision兩步法檢測87例人腦少突膠質(zhì)細胞瘤以及23例腫瘤旁腦組織中FABP5及Ki-67的表達。分析FABP5在少突膠質(zhì)細胞瘤中的表達與Ki-67、臨床病理參數(shù)以及預(yù)后的關(guān)系。結(jié)果 (1)FABP5在少突膠質(zhì)細胞瘤中高表達率為63.2%(55/87),顯著高于腫瘤旁腦組織(34.8%,8/23)(P0.05);(2)FABP5在少突膠質(zhì)細胞瘤中的表達與組織學分級(P=0.018,rs=0.254)、Ki-67表達呈正相關(guān)(P=0.003,rs=0.318);(3)單因素生存分析顯示,FABP5蛋白、Ki-67、化療、年齡與少突膠質(zhì)細胞瘤患者預(yù)后相關(guān)(P0.05)。結(jié)論 FABP5可能在少突膠質(zhì)細胞瘤的發(fā)生、發(fā)展過程中發(fā)揮重要作用,有望成為判斷少突膠質(zhì)細胞瘤患者疾病進展及預(yù)后的生物學指標。
[Abstract]:Objective to investigate fatty acid binding protein 5 fatty acid-binding protein 5. FABP5). In oligodendrocytoma and its clinical significance. Methods Immunohistochemical en was used. The expression of FABP5 and Ki-67 in 87 cases of oligodendrocytoma and 23 cases of paraneoplastic brain tissue were detected by Vision two-step method. The expression of FABP5 in oligodendrocytoma was analyzed. Ki-67. Results the high expression rate of FABP5 in oligodendrocytoma was 63.255 / 87, which was significantly higher than that in paratumor brain tissue (34.8%). 8 / 23 P0.05; The expression of FABP5 in oligodendrocytoma was positively correlated with the expression of Ki-67 in the histologic grade (P0. 018 ~ 0. 254) of oligodendrocytoma. The expression of FABP5 in oligodendrocytoma was positively correlated with the expression of Ki-67. RSM 0.318; Univariate survival analysis showed FABP5 protein Ki-67, chemotherapy. Age is associated with prognosis of oligodendrocytoma. Conclusion FABP5 may play an important role in the occurrence and development of oligodendrocytoma. It is expected to be a biological index to judge the disease progression and prognosis in oligodendrocytoma patients.
【作者單位】： 安徽醫(yī)科大學病理學教研室;安徽醫(yī)科大學第一附屬醫(yī)院病理科;
【基金】：國家自然科學基金(81201052)
【分類號】：R739.41
【正文快照】： 作者單位:1安徽醫(yī)科大學病理學教研室,合肥2300322安徽醫(yī)科大學第一附屬醫(yī)院病理科,合肥230022膠質(zhì)瘤是中樞神經(jīng)系統(tǒng)中最為常見的原發(fā)性腫瘤,少突膠質(zhì)細胞瘤(oligodendroglioma)屬于膠質(zhì)瘤的一種獨立類型,占顱內(nèi)腫瘤的4%~5%[1]。由于少突膠質(zhì)細胞瘤具有獨特的分子遺傳學改變、，

本文編號：1369544