【摘要】：目的探討退白湯聯(lián)合窄譜中波紫外線(NB-UVB)治療尋常型白癜風(fēng)的療效及對外周血IL-17,IL-22,IL-23的調(diào)節(jié)作用與臨床意義。方法 138例尋常型白癜風(fēng)患者分為治療組、對照Ⅰ組、對照Ⅱ組各46例,每組又分為進(jìn)展期和穩(wěn)定期各23例。治療組內(nèi)服退白湯,2次/d,并予NB-UVB局部照射,2次/周;對照Ⅰ組單純內(nèi)服退白湯;對照Ⅱ組單純使用NB-UVB局部照射,方法均同治療組,3組療程均為12周。另選志愿者30例作為健康對照組。分別于治療前和治療后檢測健康對照組以及白癜風(fēng)患者IL-17,IL-22,IL-23含量,同時評價臨床療效。結(jié)果治療組進(jìn)展期和穩(wěn)定期有效率分別為91.30%和65.22%,對照Ⅰ組分別為65.22%和34.78%,對照Ⅱ組分別為60.87%和30.43%,治療組與對照Ⅰ組、對照Ⅱ組進(jìn)展期和穩(wěn)定期分別比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05);治療組進(jìn)展期和穩(wěn)定期、對照Ⅰ組和對照Ⅱ組進(jìn)展期IL-17,IL-22,IL-23分別與治療前比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05 or P0.01);治療組與對照Ⅰ組、對照Ⅱ組比較,進(jìn)展期和穩(wěn)定期中上述各項(xiàng)指標(biāo)差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論退白湯聯(lián)合NB-UVB治療尋常型白癜風(fēng)療效顯著,可能是通過降低患者血清中Th17細(xì)胞相關(guān)因子IL-17,IL-22,IL-23的含量來發(fā)揮治療白癜風(fēng)的作用。
[Abstract]:Objective to investigate the efficacy of Huibai decoction combined with narrow band ultraviolet (NB-UVB) in the treatment of vitiligo vulgaris and the regulatory effect and clinical significance of IL-17,IL-22,IL-23 in peripheral blood. Methods 138 patients with vitiligo vulgaris were divided into treatment group (n = 46) and control group (n = 46). Each group was divided into progressive stage (n = 23) and stable stage (n = 23). The treatment group was treated with Tuibai decoction twice a day, and NB-UVB was irradiated locally twice a week, while the control group 鈪，

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