【摘要】：目的檢測白癜風患者外周血CD4~+、CD8~+T細胞及CD4~+CD25~+調(diào)節(jié)性T細胞(Treg)的水平,同時對退白顆粒聯(lián)合NB-UVB治療后兩者的水平進行檢測,探討兩者與該病的關(guān)系。方法采用流式細胞儀對120例白癜風患者及30例健康對照組外周血CD4~+、CD8~+T細胞及CD4~+CD25~+Treg細胞水平進行檢測,同時120例患者分為3組,各40例。聯(lián)合治療組采用退白顆粒聯(lián)合NB-UVB治療、對照Ⅰ組采用單獨NB-UVB治療,對照Ⅱ組采用退白顆粒治療,療程為3月,對3組患者治療前后CD4~+/CD8~+比值及CD4~+CD25~+Treg水平與健康對照組進行比較。結(jié)果白癜風患者外周血CD4~+T淋巴細胞明顯降低,而CD8~+T淋巴細胞則明顯升高,與健康對照組比較均有統(tǒng)計學差異(P0.01);進展期患者CD4~+/CD8~+比值明顯低于穩(wěn)定期(P0.01),穩(wěn)定期與健康對照組比較無統(tǒng)計學差異(P0.05);白癜風患者CD4~+CD25~+Treg細胞百分率明顯低于健康對照組(P0.01),且進展期患者CD4~+CD25~+Treg細胞比穩(wěn)定期下降更明顯(P0.01)。采用退白顆粒聯(lián)合NB-UVB治療后CD4~+/CD8~+比值及CD4~+CD25~+Treg明顯上調(diào),與單獨NB-UVB和單獨退白顆粒治療比較,差異有顯著性意義(P0.01或P0.05)。結(jié)論 CD4~+/CD8~+比值的失衡與CD4~+CD25~+Treg數(shù)量的異常可能參與了白癜風的發(fā)病,退白顆粒聯(lián)合NB-UVB可能通過調(diào)節(jié)兩者的水平對該病發(fā)揮治療作用。
[Abstract]:Objective to detect the levels of CD4~, CD8~ T cells and CD4~ CD25~ regulatory T cell (Treg) in peripheral blood of patients with vitiligo. Methods the levels of CD4~, CD8~ T cells and CD4~ CD25~ Treg cells in peripheral blood of 120 patients with vitiligo and 30 healthy controls were measured by flow cytometry. The combined treatment group was treated with Tubai granule combined with NB-UVB, the control group was treated with NB-UVB alone, and the control group 鈪，

本文編號：2324688