本文選題：非阿司匹林類非甾體抗炎藥 + 皮膚癌　； 參考：《腫瘤防治研究》2014年08期

【摘要】：目的評價非阿司匹林類非甾體抗炎藥與皮膚癌發(fā)病風險的關系。方法檢索PubMed(Medline),EMBASE,BIOSIS,Cochrane圖書館,中國知網(wǎng)數(shù)據(jù)庫(CNKI)獲取有關非阿司匹林類非甾體抗炎藥與皮膚癌發(fā)病風險的研究。按照納入標準進行文獻篩查、質量評價和資料提取。應用Stata軟件計算總體OR值及95%置信區(qū)間,并進行偏倚分析。當異質性可以接受時,選用固定效應模型對各研究原始數(shù)據(jù)進行合并。結果納入非阿司匹林類非甾體抗炎藥與皮膚癌發(fā)病風險的相關臨床研究文獻10篇,共12個獨立研究,累計皮膚癌患者482 264例,合并分析結果:OR值為1.00,95%CI:0.98~1.02。結論無足夠的證據(jù)證明非阿司匹林類非甾體抗炎藥與皮膚癌發(fā)病風險相關。仍需大規(guī)模臨床隨機對照試驗來證實該結果。
[Abstract]:Objective to evaluate the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of skin cancer. Methods A study on non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of skin cancer was obtained by searching the PubMeden Medline EMBASE Bios Cochrane Library and CNKI. Document screening, quality evaluation and data extraction according to inclusion criteria. Total OR and 95% confidence interval were calculated by Stata software and bias analysis was carried out. When heterogeneity is acceptable, fixed effect models are used to merge the original data. Results there were 10 clinical studies on non-aspirin non-steroidal anti-inflammatory drugs and the risk of skin cancer. There were 12 independent studies in which there were 482,264 patients with skin cancer. The combined analysis showed that the OR value of the combined analysis was 1.0095 CI: 0.98 + 1.02. Conclusion there is insufficient evidence that non-aspirin non-steroidal anti-inflammatory drugs are associated with the risk of skin cancer. Large-scale randomized controlled trials are still needed to confirm the results.
【作者單位】： 南方醫(yī)科大學南方醫(yī)院肝臟腫瘤中心;南方醫(yī)科大學腫瘤中心;南方醫(yī)科大學中西醫(yī)結合醫(yī)院腫瘤科;
【基金】：廣東省自然科學基金重點項目(10251051501000008)
【分類號】：R739.5

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