本文選題：血管肉瘤 + 神經(jīng)鞘瘤��； 參考：《臨床與實(shí)驗(yàn)病理學(xué)雜志》2014年07期

【摘要】：目的觀(guān)察源于神經(jīng)鞘瘤的血管肉瘤臨床病理學(xué)特征,探討與神經(jīng)源性腫瘤相關(guān)的血管肉瘤組織學(xué)特征及影響預(yù)后因素。方法回顧性分析源于神經(jīng)鞘瘤上皮樣血管肉瘤的臨床病理特征、免疫表型、治療及預(yù)后,并復(fù)習(xí)相關(guān)文獻(xiàn)。結(jié)果患者男性,右上臂有一無(wú)痛性腫塊。腫塊呈結(jié)節(jié)樣,切面呈囊實(shí)性,腫瘤形態(tài)呈多形性,可見(jiàn)梭形細(xì)胞區(qū)域,部分區(qū)域細(xì)胞豐富,二者截然分界,細(xì)胞豐富區(qū)見(jiàn)由不規(guī)則血管構(gòu)成的疏松區(qū),并見(jiàn)上皮樣細(xì)胞成片分布或呈靶環(huán)樣排列,核分裂象易見(jiàn)。梭形細(xì)胞表達(dá)S-100蛋白,豐富區(qū)域S-100蛋白表達(dá)缺失,但表達(dá)GFAP,富于血管的腫瘤細(xì)胞表達(dá)CD34、CD31、FⅧRAg,上皮樣細(xì)胞表達(dá)廣譜CK�；颊咝g(shù)后接受放療,隨訪(fǎng)34個(gè)月,未見(jiàn)復(fù)發(fā)或轉(zhuǎn)移。結(jié)論源于神經(jīng)鞘瘤的血管肉瘤極為少見(jiàn),惡性程度高。腫瘤直徑(5cm)、細(xì)胞核分裂計(jì)數(shù)、手術(shù)切緣陽(yáng)性以及伴有Ⅰ型神經(jīng)纖維瘤病(neurofibromatosis type 1,NF-1)均為其預(yù)后不良因素。
[Abstract]:Objective to observe the clinicopathological features of angiosarcoma derived from neurilemmoma and to investigate the histological features and prognostic factors of angiosarcoma associated with neurogenic tumors. Methods the clinicopathological features, immunophenotype, treatment and prognosis of epithelioid angiosarcoma derived from schwannoma were retrospectively analyzed. Results the patient had a painless mass in his right upper arm. The tumor was nodular, cystic and solid, and the shape of the tumor was pleomorphic. The fusiform cell area was seen, and some of the regions were rich in cells. The two areas were separated completely, and the loose areas composed of irregular blood vessels could be seen in the rich areas. The epithelioid cells were distributed or arranged like target rings, and mitotic images were easy to be seen. S-100 protein was expressed in fusiform cells, S-100 protein was absent in rich region, GFAPs were expressed, CD34- CD31- F 鈪，

本文編號(hào)：1853428