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  本文選題：慢性光化性皮炎　切入點：最小紅斑量　出處：《昆明醫(yī)科大學》2012年碩士論文

【摘要】：目的利用云南地區(qū)慢性光化性皮炎(chronic actinic dermatitis, CAD)發(fā)病率高的優(yōu)勢,對云南地區(qū)CAD患者和正常人的最小紅斑量和光斑貼試驗的差異進行測定和分析,并探討IL-6、TNF-a與CAD患者發(fā)病的相關(guān)性。 方法采用SUV1000型日光模擬器對21例CAD患者和40例正常對照者進行最小紅斑量的測定,并采用SS-03AB型紫外線光療儀和標準光斑貼試驗試劑盒對21例CAD患者和21例正常對照者進行光斑貼試驗(光源：UVA5J/cm2)應用ELISA的方法檢測CAD患者、正常對照者血清中IL-6、TNF-a的含量。應用SPSS17.0軟件對數(shù)據(jù)資料進行統(tǒng)計分析。 結(jié)果1、CAD患者組的UVA-MED、UVB-MED分別為26.05J/cm2、28.32mJ/cm2;正常對照組的UVA-MED、UVB-MED分別為50.06J/cm2、38.25mJ/cm2. CAD患者的UVA-MED、UVB-MED較正常人對照組明顯降低,P值均0.05。正常對照組內(nèi)UVA-MED和UVB-MED兩性間差異無統(tǒng)計學意義,P均0.05。2、CAD患者、正常人中光斑貼試驗陽性率分別為57.1%,47.6%。CAD患者最常見的光變應原為芳香混合物(31.25%)、D-松蘿酸(12.50%)和木材合成物(12.50%)；正常人最常見的光變應原為芳香混合物(23.08%)、D-松蘿酸(15.38%)、秘魯香脂(15.38%)。經(jīng)檢驗CAD患者與正常人對照組的光斑貼試驗結(jié)果差異無統(tǒng)計學意義(P0.05)。3、IL-6在CAD患者組血清中為0.953±0.198(pg/ml),低于正常人血清中(3.165±0.772pg/ml)的水平,差異有統(tǒng)計學意義(P0.05)。CAD患者組血清中TNF-a和正常人對照組血清水平無明顯差異,無統(tǒng)計學意義(P0.05)。 結(jié)論1、最小紅斑量的測定提示CAD的發(fā)病與UVA、UVB的照射有關(guān),其中UVA更為敏感。2、CAD患者及正常人對照組都對多種(光)接觸性變應原呈陽性反應。 3、CAD的發(fā)病可能和IL-6的降低有一定的關(guān)系。
[Abstract]:Objective to measure and analyze the difference of minimal erythema amount and light spot patch test between CAD patients and normal subjects in Yunnan province by using the high incidence rate of chronic actinic dermatitis (CAD), and to explore the correlation between IL-6 actinic TNF-a and the incidence of CAD. Methods the minimal erythema was measured in 21 patients with CAD and 40 normal controls by using SUV1000 solar simulator. Using SS-03AB ultraviolet phototherapy instrument and standard spot patch test kit, 21 CAD patients and 21 normal control subjects were tested by ELISA with the light source of: UVA 5J / cm 2. The contents of IL-6 and TNF-a in serum of normal controls were analyzed by SPSS17.0 software. Results 1 the UVA-MED- UVB-MED was 26.05J / cm ~ (-2) (28.32mJ / cm ~ (-2)) in CAD group and 50.06J / cm ~ (-2) UVB-MED was 58.25mJ / cm ~ (2) in normal control group. The value of UVA-MEDUVB-MED in CAD patients was significantly lower than that in normal control group (0.05). There was no significant difference between UVA-MED and UVB-MED in normal control group (P < 0.05). The most common photoallergens in CAD patients were the aromatic mixture of 31. 25% D- arboxylic acid 12.50) and wood compound 12. 50%, respectively. The most common photoallergens in normal people were the aromatic mixture of 23. 08D-pinealic acid 15.38%, Peruvian balsamic acid 15. 38%. There was no significant difference in the results of spot patch test between CAD patients and normal controls. The serum level of IL-6 in CAD patients was 0.953 鹵0.198 mg / ml, which was lower than that in normal controls (3.165 鹵0.772 PG / ml). There was no significant difference in serum levels of TNF-a between the patients with P0.05 and the control group, and there was no significant difference in the serum levels between the two groups. Conclusion 1. The determination of minimal erythema quantity indicates that the pathogenesis of CAD is related to the exposure to UVB, and UVA is more sensitive to UVA and normal control group is positive for many (light) contact allergens. 3 the incidence of IL-6 may be related to the decrease of IL-6.
【學位授予單位】：昆明醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R758.14

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