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  本文關鍵詞： 尋常型銀屑病 復發(fā)型銀屑病 玉屏銀屑方 緩解期 T細胞亞群　出處：《山東中醫(yī)藥大學》2012年碩士論文　論文類型：學位論文

【摘要】：目的：觀察玉屏銀屑方延長尋常型復發(fā)型銀屑病緩解期的療效及預防干預用藥前后患者外周血T細胞亞群水平的變化，初步探討玉屏銀屑方延長尋常型復發(fā)型銀屑病緩解期的作用機理。 方法：收集病例共87例，隨機分為玉屏銀屑方組30例（A組）、轉移因子膠囊組27例（B組）和停藥組30例（C組）。A組和B組治療4周后停藥，觀察一年；C組入組即停藥與A組做平行對照，觀察一年。A組隨機抽取20人，于入組前和治療4周后進行外周血T細胞亞群檢測，并與20個正常人T細胞亞群做對照分析。對所有入組患者隨訪觀察一年，主要觀察評估PASI、瘙癢程度、QOL、復發(fā)時間和不良事件。 結果：T細胞亞群檢測：A組患者治療前，患者外周血T淋巴細胞亞群低于正常范圍，治療后T細胞亞群水平相比治療前改善顯著。 臨床觀察結果分析：復發(fā)率比較，A組復發(fā)率明顯低于C組。復發(fā)患者PASI評分比較，A組復發(fā)患者PASI評分顯著低于C組，且A組復發(fā)患者PASI評分增加幅度明顯低于C組。瘙癢程度比較，A組復發(fā)患者瘙癢程度顯著低于C組，且A組復發(fā)患者瘙癢程度的增加幅度明顯低于C組。入組患者QOL評分比較，A組患者結束觀察研究時QOL評分非常顯著低于C組，并進一步提示A組患者前后QOL評分減少數(shù)值非常顯著大于C組。緩解時間比較，A組復發(fā)患者本次緩解期顯著比C組延長，并進一步提示A組復發(fā)患者緩解期延長時間非常顯著高于C組。 A組與B組以上臨床觀察結果分析各項比較均無顯著差異，各項比較均基本持平。 結論：玉屏銀屑方能夠顯著延長尋常型復發(fā)型銀屑病患者的緩解期，能夠改善T細胞的免疫功能和免疫平衡。
[Abstract]:Objective: to observe the curative effect of Yuping Yinfeng recipe in prolonging the remission period of recurrent psoriasis vulgaris and the changes of T cell subsets in peripheral blood of patients with Psoriasis vulgaris before and after preventive intervention. Objective: to explore the mechanism of Yuping Yinfeng recipe in prolonging the remission period of recurrent psoriasis vulgaris. Methods: 87 cases were randomly divided into group A (30 cases), group A (27 cases), group B (27 cases), group B (30 cases), group C (30 cases) and group B (30 cases). The T lymphocyte subsets of peripheral blood were detected before and after 4 weeks of treatment in group A, and 20 patients in group A were randomly selected for one year. All the patients were followed up for one year to evaluate PASI, the degree of pruritus and QOLs, recurrence time and adverse events. Results before treatment, T lymphocyte subsets in peripheral blood of patients in group A were lower than those in normal range, and the level of T lymphocyte subsets was significantly improved after treatment. Analysis of clinical observation results: the recurrence rate in group A was significantly lower than that in group C, the PASI score in group A was significantly lower than that in group C, and the PASI score in group A was significantly lower than that in group C. The degree of pruritus in group A was significantly lower than that in group C, and the degree of pruritus in group A was significantly lower than that in group C. The degree of pruritus in group A was significantly lower than that in group C. the QOL score of group A was significantly lower than that of group C at the end of the study. It was further suggested that the decrease of QOL score in group A was significantly larger than that in group C. the remission time of group A was significantly longer than that of group C, and the remission time of group A was significantly longer than that of group C. It was further suggested that the duration of remission in group A was significantly longer than that in group C. There was no significant difference in clinical observation results between group A and group B. Conclusion: Yuping Yinfeng prescription can significantly prolong the remission period of patients with recurrent psoriasis vulgaris and improve the immune function and balance of T cells.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R758.63

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