【摘要】：目的探討在2型糖尿病(T2DM)患者中血清總膽紅素(TBIL)、間接膽紅素(IBIL)水平與頸動脈內膜-中層厚度(CIMT)的關系。方法選取住院的T2DM患者共349例,根據(jù)彩色多普勒超聲儀測量CIMT的結果將頸動脈硬化和(或)斑塊視為病變組(n=111),反之為無病變組(n=238),比較兩組間3種血清膽紅素水平及其他生化指標與頸動脈病變的關系,同時分析CIMT的影響因素。結果病變組的CIMT較無病變組明顯增厚(P0.001),而TBIL及IBIL的水平低于無病變組(P0.05)。進一步按男女性別分層比較兩組3種血清膽紅素水平與患者頸動脈病變的關系,發(fā)現(xiàn)在男性中,病變組血清TBIL及IBIL的水平較無病變組明顯降低(P0.05)。CIMT相關因素的Pearson分析結果顯示:CIMT與年齡、收縮壓、空腹血糖及Hb A1C呈正相關,而與血清IBIL水平呈負相關(均P0.05)。結論作為內源性的抗氧化劑膽紅素在T2DM患者中同樣具有保護血管內皮功能的作用,并且在一定程度上可作為動脈粥樣硬化的預測指標,因此應重視動脈粥樣硬化危險因素的預防,關注膽紅素的抗氧化保護作用。
[Abstract]:Objective to investigate the relationship between serum total bilirubin (TBIL), indirect bilirubin (IBIL) level and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 349 patients with T2DM were enrolled in this study. according to the results of CIMT measured by color Doppler ultrasound, carotid atherosclerosis and / or plaques were regarded as lesion group (n 鈮，

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