【摘要】：目的研究運(yùn)動(dòng)鍛煉及雌激素受體(ER)-β基因多態(tài)性與女性老年性骨質(zhì)疏松(ADOP)的相關(guān)性。方法 420例長(zhǎng)期運(yùn)動(dòng)鍛煉老年女性和415例非長(zhǎng)期運(yùn)動(dòng)鍛煉老年女性,定量超聲骨質(zhì)密度儀檢測(cè)兩組右側(cè)足跟骨寬帶超聲衰減值,PCR-RFLP檢測(cè)兩組ER-β基因多態(tài)性。結(jié)果長(zhǎng)期運(yùn)動(dòng)鍛煉組ADOP的患病率明顯低于非長(zhǎng)期運(yùn)動(dòng)鍛煉組(P0.01)。ER-β基因RsaⅠ等位基因分布頻率在兩組中存在顯著差異(P0.01),r等位基因患ADOP的風(fēng)險(xiǎn)是R等位基因的1.565倍(OR=1.565,95%CI:1.270~1.928)。長(zhǎng)期運(yùn)動(dòng)鍛煉組攜帶AluⅠ酶切位點(diǎn)的a等位基因分布頻率明顯少于非長(zhǎng)期運(yùn)動(dòng)鍛煉組(P0.01)。結(jié)論長(zhǎng)期運(yùn)動(dòng)鍛煉對(duì)ADOP有防治作用。ER-βRsaⅠ酶切位點(diǎn)的r等位基因可能是ADOP的遺傳易感基因。AluⅠ酶切位點(diǎn)的a等位基因是對(duì)運(yùn)動(dòng)鍛煉的敏感基因。
[Abstract]:Objective to study the relationship between exercise and estrogen receptor (ER)-尾 gene polymorphism and senile osteoporosis (ADOP) in women. Methods Wideband ultrasonic attenuation of right calcaneus was measured by quantitative ultrasound bone densitometer and ER- 尾 gene polymorphism was detected by PCR-RFLP in 420 elderly women with long-term exercise and 415 elderly women with non-long-term exercise. Results the prevalence of ADOP in the long-term exercise group was significantly lower than that in the non-long-term exercise group (P0.01). The frequency of Rsa 鈪，

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