【摘要】：目的：探討B(tài)MD對骨質疏松性骨折的預測及FRAX有或無BMD情況下哪種方法能更好預測骨質疏松性骨折。方法：對2012年在昆明醫(yī)科大學第一附屬醫(yī)院體檢的1000例在昆明長期居住(10年)、年齡40-90歲,行DXA檢測股骨頸、大粗隆、全髖或L1、L2、L3、L4、L1-L4骨密度的女性人群,進行兩年后的電話回訪。共計回訪有效人數869例,失訪人數131人。將此869例人群劃分為骨量正常、骨量減少、骨質疏松三組。骨量減少人群中,測股骨頸BMD的為F組,測腰椎BMD的為NF組,分析比較F組及NF組人群的相關性。結果：在218例F組的人群中有骨折患者的股骨頸BMD、大粗隆BMD、全髖部BMD均較無骨折的患者低(P0.05),差異有統(tǒng)計學意義。FRAX使用BMD計算出髖部骨折概率及主要骨松性骨折概率分別為(2.981±3.360)及(7.169±4.684),高于未使用BMD計算的骨折概率(P0.01)。F組的218例女性中FRAX為高風險的骨折概率(13.9%)大于NF組的215例女性中FRAX為高風險的骨折概率(0%),卡方值為0.244,P0.05。每日日曬時間和運動時間與FRAX計算主要骨質疏松骨折概率無相關性(P0.05),與髖部骨折概率呈負相關(P0.001)；服用維生素D與FRAX計算主要骨質疏松骨折概率和10年髖部骨折概率均成負相關(P0.001)。結論：BMD和FRAX均可預測骨質疏松性骨折的風險；FRAX在輸入BMD的情況下較不輸入BMD能夠更好的預測骨折。
[Abstract]:Objective: to study the prediction of osteoporotic fracture by BMD and the method of FRAX with or without BMD. Methods: 1000 patients (aged 40-90 years old) who were examined in the first affiliated Hospital of Kunming Medical University in 2012 were examined by DXA for femoral neck, trochanter, total hip or L1, L2, L3, L4. Women with L1-L4 bone density were interviewed by telephone two years later. A total of 869 cases were returned and 131 were lost. The 869 cases were divided into three groups: normal bone mass, decreased bone mass and osteoporosis. In the population with decreased bone mass, the BMD of femoral neck was measured in group F and the group of lumbar BMD was NF. The correlation between group F and group NF was analyzed and compared. Results: the total BMD of femoral neck BMD, trochanter BMD, in 218 patients with fracture in group F was lower than that in patients without fracture (P0.05). FRAX used BMD to calculate the probability of hip fracture and the probability of main bone loose fracture were (2.981 鹵3.360) and (7.169 鹵4.684), respectively. The probability of fracture with high risk of FRAX was higher (13.9%) than that of 215 women without BMD (P0.01). F group, P 0.01). F group, 0%). The chi-square value was 0.244, higher than that of FRAX group (0%). P0.05. There was no correlation between daily sunshine time and exercise time and the probability of main osteoporotic fracture calculated by FRAX (P0.05), but there was a negative correlation with hip fracture probability (P0. 001). There was a negative correlation between vitamin D intake and the probability of main osteoporotic fracture and 10 years hip fracture calculated by FRAX (P0. 001). Conclusion: both BMD and FRAX can predict the risk of osteoporotic fracture and FRAX can predict the fracture better than that without BMD.
【學位授予單位】：昆明醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R580

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2 闕文君;馮正平;;骨轉換生化標志物的研究進展[J];中國骨質疏松雜志;2014年05期

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