【摘要】：目的探究2型糖尿病患者腎功能進(jìn)展的危險(xiǎn)因素,為臨床防治工作提供更多有價(jià)值的參考依據(jù)。方法根據(jù)標(biāo)準(zhǔn)選擇5043例2型糖尿病患者,按估計(jì)腎小球?yàn)V過率(eGFR)分為eGFR60和eGFR≥60組,對(duì)照比較各組患者人口學(xué)資料及實(shí)驗(yàn)室指標(biāo)的差異。將相關(guān)危險(xiǎn)因素分層后比較eGFR下降情況。分析相關(guān)危險(xiǎn)因素控制狀態(tài)與eGFR下降的情況。分析eGFR與不同指標(biāo)的相關(guān)性。采取Logistic回歸法分析2型糖尿病患者eGFR下降的獨(dú)立危險(xiǎn)因素。結(jié)果與eGFR≥60組相比,eGFR60組年齡大[(64.67±10.16比57.00±10.31)歲,P0.01],糖尿病病程長[12.00(7.00,18.00)比5.00(2.00,10.00)年,P0.01],家族史比率(62.15%比29.22%,X~2=342.010,P0.01)、高血壓患病率(78.47%比47.02%,X~2=283.953,P0.01)和動(dòng)脈硬化患病率(63.19%比37.83%,X~2=188.843,P0.01)高。eGFR下降的發(fā)生率隨年齡增長(X~2=397.534,P0.01)、病程延長(X~2=398.968,P0.01)、尿蛋白水平升高(X~2=1840.510,P0.01)、有家族史(X~2=338.481,P0.01)、患高血壓(X~2=283.953,P0.01)、動(dòng)脈硬化(X~2=188.843,P0.01)及高尿酸血癥(X~2=566.289,P0.01)而升高。血糖、血壓、血脂控制情況與腎功能下降無明顯相關(guān)(X~2=1.117,P=0.572;X~2=3.207,P=0.073;X~2=1.798,P=0.180)。相關(guān)性分析顯示eGFR與年齡(r=-0.573,P0.01)、糖尿病病程(r=-0.353,P0.01)、收縮壓(r=-0.176,P0.01)、24h尿蛋白量(r=-0.438,P0.01)、UA(r=-0.214,P0.01)、Hcy(r=-0.245,P0.01)呈負(fù)相關(guān)。Logistic回歸分析顯示,年齡、DM病程、DM家族史、24h尿蛋白量、SUA是eGFR下降的危險(xiǎn)因素,[OR=1.100,95%CI(1.080,1.120),P0.01;OR=1.078,95%CI(1.054,1.104),P0.01;OR=3.829,95%CI(2.762,5.309),P0.01;OR=3.175,95%CI(2.773,3.636),P0.01;OR=1.012,95%CI(1.011,1.014),P0.01]。結(jié)論年齡、糖尿病病程、糖尿病家族史、24h尿蛋白、血尿酸是糖尿病患者腎功能進(jìn)展的危險(xiǎn)因素。
[Abstract]:Objective to explore the risk factors of renal function progression in type 2 diabetes mellitus and to provide more valuable reference for clinical prevention and treatment. Methods 5043 patients with type 2 diabetes mellitus were selected according to the standard. According to the estimated glomerular filtration rate (eGFR), the patients were divided into eGFR60 and eGFR 鈮，

本文編號(hào)：2415929