豬油與植物黃油對大鼠不同部位脂肪組織單核細胞趨化蛋白-1表達水平的影響
發(fā)布時間：2018-11-22 17:23
【摘要】：目的探究豬油與植物黃油飲食對不同部位脂肪組織單核細胞趨化蛋白-1(MCP-1)表達水平的影響。方法 2015年4—6月,選取健康的初斷乳SPF級、Wistar雄性大鼠49只,隨機分為對照組(CON組,n=7)、豬油組(L組,n=21)、植物黃油組(M組,n=21)。CON組大鼠采用基礎(chǔ)飼料喂養(yǎng),L組大鼠采用含豬油的高脂飼料喂養(yǎng),M組大鼠采用含植物黃油的高脂飼料喂養(yǎng)。3組大鼠均飼養(yǎng)8周,結(jié)束時將L組和M組大鼠按體質(zhì)量增加量的前1/3和后1/3分別分為豬油-肥胖傾向組(L-OP組,n=7)、植物黃油-肥胖傾向組(M-OP組,n=7)和豬油-肥胖抵抗組(L-OR組,n=7)、植物黃油-肥胖抵抗組(M-OR組,n=7),其余棄去。比較5組大鼠體質(zhì)量增加量、附睪周脂肪系數(shù)、腎周脂肪系數(shù)及皮下、附睪周、腎周脂肪組織MCP-1表達水平。結(jié)果 L-OP組、MOP組大鼠體質(zhì)量增加量均大于CON組(P0.05);L-OP組、M-OP組、M-OR組大鼠附睪周脂肪系數(shù)均大于CON組(P0.05);L-OP組、L-OR組、M-OP組、M-OR組大鼠腎周脂肪系數(shù)均大于CON組(P0.05)。5組大鼠附睪周脂肪組織MCP-1表達水平比較,差異無統(tǒng)計學意義(P0.05);L-OP組、L-OR組、M-OP、M-OR組大鼠皮下脂肪組織MCP-1表達水平均高于CON組(P0.05);M-OP組、M-OR組大鼠腎周脂肪組織MCP-1表達水平均高于CON組(P0.05)。結(jié)論與豬油相比,植物黃油更能引起皮下、腎周脂肪組織MCP-1表達水平升高。
[Abstract]:Objective to investigate the effect of lard and vegetable butter diet on the expression of monocyte chemoattractant protein-1 (MCP-1) in adipose tissues. Methods from April to June 2015, 49 male Wistar rats were randomly divided into three groups: control group (CON group, n = 7), lard group (L group, n = 21), vegetable butter group (M group, n = 21). CON group). Rats in group L were fed with high fat diet containing lard, and rats in group M were fed with high fat diet containing vegetable butter. At the end of the study, rats in group L and group M were divided into lard obesity prone group (L-OP group, n = 7) and butter-obesity prone group (M-OP group), respectively. The rest were abandoned in the lard obesity resistance group (L-OR group, nong7 group), butter-obesity resistance group (M-OR group, nong7 group) and lard fat resistance group (L-OR group, nong7 group). The body weight increase, peri-epididymal fat coefficient, perirenal fat coefficient and MCP-1 expression levels in subcutaneous, peri-epididymal and perirenal adipose tissues were compared among the five groups. Results the increase of body mass in L-OP group and MOP group was higher than that in CON group (P0.05), the periepididymal fat coefficient in L-OP group, M-OP group and M-OR group was higher than that in CON group (P0.05). The perirenal fat coefficients of L-OP group, L-OR group, M-OP group and M-OR group were higher than that of CON group (P0.05). There was no significant difference in the expression of MCP-1 in peri-epididymal adipose tissue in 5 groups (P0.05). The expression of MCP-1 in subcutaneous adipose tissue of L-OP group, L-OR group and M-OPN M-OR group was higher than that of CON group (P0.05). The expression of MCP-1 in perirenal adipose tissue in M-OP group and M-OR group was higher than that in CON group (P0.05). Conclusion compared with lard, vegetable butter can induce more subcutaneous and elevated MCP-1 expression in perirenal adipose tissue.
【作者單位】： 中國醫(yī)科大學公共衛(wèi)生學院兒少衛(wèi)生與婦幼保健學教研室;鄂東醫(yī)療集團黃石市中心醫(yī)院質(zhì)量管理部;
【基金】：國家自然科學基金資助項目(81373018)
【分類號】：R589.2
本文編號：2350040
[Abstract]:Objective to investigate the effect of lard and vegetable butter diet on the expression of monocyte chemoattractant protein-1 (MCP-1) in adipose tissues. Methods from April to June 2015, 49 male Wistar rats were randomly divided into three groups: control group (CON group, n = 7), lard group (L group, n = 21), vegetable butter group (M group, n = 21). CON group). Rats in group L were fed with high fat diet containing lard, and rats in group M were fed with high fat diet containing vegetable butter. At the end of the study, rats in group L and group M were divided into lard obesity prone group (L-OP group, n = 7) and butter-obesity prone group (M-OP group), respectively. The rest were abandoned in the lard obesity resistance group (L-OR group, nong7 group), butter-obesity resistance group (M-OR group, nong7 group) and lard fat resistance group (L-OR group, nong7 group). The body weight increase, peri-epididymal fat coefficient, perirenal fat coefficient and MCP-1 expression levels in subcutaneous, peri-epididymal and perirenal adipose tissues were compared among the five groups. Results the increase of body mass in L-OP group and MOP group was higher than that in CON group (P0.05), the periepididymal fat coefficient in L-OP group, M-OP group and M-OR group was higher than that in CON group (P0.05). The perirenal fat coefficients of L-OP group, L-OR group, M-OP group and M-OR group were higher than that of CON group (P0.05). There was no significant difference in the expression of MCP-1 in peri-epididymal adipose tissue in 5 groups (P0.05). The expression of MCP-1 in subcutaneous adipose tissue of L-OP group, L-OR group and M-OPN M-OR group was higher than that of CON group (P0.05). The expression of MCP-1 in perirenal adipose tissue in M-OP group and M-OR group was higher than that in CON group (P0.05). Conclusion compared with lard, vegetable butter can induce more subcutaneous and elevated MCP-1 expression in perirenal adipose tissue.
【作者單位】： 中國醫(yī)科大學公共衛(wèi)生學院兒少衛(wèi)生與婦幼保健學教研室;鄂東醫(yī)療集團黃石市中心醫(yī)院質(zhì)量管理部;
【基金】：國家自然科學基金資助項目(81373018)
【分類號】：R589.2
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