【摘要】：肥胖及2型糖尿病是代謝紊亂相關(guān)的慢性低度系統(tǒng)炎癥狀態(tài)。半乳糖苷凝集素-3(galectin-3)是一種β-半乳糖苷結(jié)合蛋白,在炎癥、信號(hào)轉(zhuǎn)導(dǎo)、細(xì)胞增殖與分化等過(guò)程中發(fā)揮重要作用。新近的研究表明,半乳糖苷凝集素-3在患肥胖和2型糖尿病的人及鼠類體內(nèi)高表達(dá),對(duì)鼠類體脂的沉積、脂肪細(xì)胞分化、血糖濃度、胰島素敏感性、葡萄糖耐受性和系統(tǒng)炎癥等具有重要影響。本文綜述了半乳糖苷凝集素-3的結(jié)構(gòu)、分布及其對(duì)肥胖和2型糖尿病的調(diào)控作用與分子機(jī)制,以期為研發(fā)針對(duì)半乳糖苷凝集素-3靶點(diǎn)的新藥提供重要思路和參考。
[Abstract]:Obesity and type 2 diabetes are chronic low-system inflammation associated with metabolic disorders. Galactoside agglutinin-3 (galectin-3) is a 尾-galactoside binding protein, which plays an important role in inflammation, signal transduction, cell proliferation and differentiation. Recent studies have shown that galactoagglutinin-3 is highly expressed in obese and type 2 diabetic people and mice, and is sensitive to rat body fat deposition, adipocyte differentiation, blood glucose concentration, insulin sensitivity, Glucose tolerance and systemic inflammation have important effects. In this paper, the structure, distribution, regulation and molecular mechanism of galactoagglutinin-3 on obesity and type 2 diabetes mellitus were reviewed in order to provide important ideas and references for the development of new drugs targeting galactoside lectin-3 targets.
【作者單位】： 山西師范大學(xué)生命科學(xué)學(xué)院生物科學(xué)系;山西師范大學(xué)醫(yī)院內(nèi)科;
【基金】：國(guó)家自然科學(xué)基金(No.30972091) 山西省高等學(xué)校優(yōu)秀青年學(xué)術(shù)帶頭人支持計(jì)劃(No.201004) 山西省軟科學(xué)研究計(jì)劃(No.2014041062-2)資助~~
【分類號(hào)】：R587.1;R589.2
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本文編號(hào)：2227056