【摘要】：目的探討甲硫酸新斯的明對(duì)百草枯中毒的治療作用。方法回顧性分析2014年7月至2016年6月在我院治療的百草枯中毒患者43例,根據(jù)患者是否加用新斯的明治療分為常規(guī)治療組(n=21)及新斯的明組(n=22)。對(duì)比兩組患者入院時(shí),入院后48 h的血清TNF-α、IL-6、IL-10水平及急性生理學(xué)及慢性健康狀況(APACHEⅡ)評(píng)分、肺損傷評(píng)分(lung injury score,LIS);對(duì)比兩組患者3個(gè)月內(nèi)病死率。結(jié)果兩組患者入院當(dāng)天血清TNF-α、IL-6、IL-10水平相近,差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療2 d后,新斯的明組血清TNF-α、IL-6水平明顯低于常規(guī)治療組(P0.01)。兩組患者入院當(dāng)天APACHEⅡ評(píng)分、LIS評(píng)分相近,差異無統(tǒng)計(jì)學(xué)意義(P0.05);分別治療2 d后,新斯的明組APACHEⅡ評(píng)分、LIS評(píng)分低于常規(guī)治療組(P0.05)。兩組患者在3 d內(nèi)病死率差異無統(tǒng)計(jì)學(xué)意義(P0.05),但新斯的明組7 d及30 d病死率低于常規(guī)治療組(P0.05)。結(jié)論百草枯患者早期加用新斯的明治療,可減少TNF-α、IL-6炎性介質(zhì)的合成,從而維持各個(gè)器官正常功能,減輕肺損傷,提高生存率。
[Abstract]:Objective to investigate the therapeutic effect of neostigmine methyl sulfate on paraquat poisoning. Methods 43 cases of paraquat poisoning treated in our hospital from July 2014 to June 2016 were retrospectively analyzed. According to whether the patients were treated with neostigmine or not, they were divided into two groups: routine treatment group (n = 21) and neostigmine group (n = 22). The levels of serum TNF- 偽 IL-6 IL-10, acute physiology and chronic health status (APACHE 鈪，

本文編號(hào)：2221429