苯溴馬龍與非布司他治療老年痛風(fēng)患者的療效及安全性
發(fā)布時間：2018-08-04 18:08
【摘要】：目的探討非布司他與苯溴馬龍治療老年痛風(fēng)患者的臨床效果及安全性。方法采取前瞻性研究方法,120例老年痛風(fēng)患者采用隨機數(shù)字表法分為試驗組和對照組各60例。試驗組采用非布司他治療,對照組采用苯溴馬龍治療,兩組均連續(xù)用藥24 w后對比臨床效果及實驗室指標(biāo)。結(jié)果兩組治療前、治療6 w、12 w后血尿酸(SUA)水平差異無統(tǒng)計學(xué)意義(P0.05)。治療第24周后,試驗組SUA水平顯著低于對照組(P0.05);關(guān)節(jié)疼痛、關(guān)節(jié)腫脹、關(guān)節(jié)壓痛、關(guān)節(jié)活動障礙評分、血沉(ESR)、C反應(yīng)蛋白(CRP)、血清可溶性細胞黏附因子(s ICAM)-1、血清內(nèi)皮素(ET)-1水平顯著低于對照組(P0.05);尿素氮(BUN)、肌酐(Cr)水平顯著低于對照組(P0.05)。結(jié)論非布司他治療老年痛風(fēng)患者的效果優(yōu)于苯溴馬龍,同時對患者的腎功能損害程度更小。
[Abstract]:Objective to investigate the clinical efficacy and safety of fentast and benzyl bromide Ma Long in the treatment of elderly patients with gout. Methods 120 elderly patients with gout were randomly divided into trial group (n = 60) and control group (n = 60). The experimental group was treated with non-burestar and the control group was treated with benzyl bromide Ma Long. The clinical effects and laboratory indexes were compared after 24 weeks of continuous administration of benzene bromide in both groups. Results there was no significant difference in serum uric acid (SUA) levels between the two groups before and after treatment for 6 weeks and 12 weeks (P0.05). After 24 weeks of treatment, the level of SUA in the experimental group was significantly lower than that in the control group (P0.05). The levels of serum soluble cell adhesion factor (s ICAM) -1) and endothelin (ET) 1 (ET) -1) in ESR (ESR) C reactive protein (CRP),) were significantly lower than those in control group (P0.05), and the level of (BUN), creatinine (Cr) in urea nitrogen was significantly lower than that in control group (P0.05). Conclusion the efficacy of fentinastar in the treatment of senile gout patients is better than that of phenylbromine Ma Long, and the renal function is less damaged.
【作者單位】： 綿陽市中心醫(yī)院風(fēng)濕免疫科;
【基金】：綿陽市痛風(fēng)及高尿酸血癥慢病管理系統(tǒng)構(gòu)建項目(14Q0063)
【分類號】：R589.7
本文編號：2164683
[Abstract]:Objective to investigate the clinical efficacy and safety of fentast and benzyl bromide Ma Long in the treatment of elderly patients with gout. Methods 120 elderly patients with gout were randomly divided into trial group (n = 60) and control group (n = 60). The experimental group was treated with non-burestar and the control group was treated with benzyl bromide Ma Long. The clinical effects and laboratory indexes were compared after 24 weeks of continuous administration of benzene bromide in both groups. Results there was no significant difference in serum uric acid (SUA) levels between the two groups before and after treatment for 6 weeks and 12 weeks (P0.05). After 24 weeks of treatment, the level of SUA in the experimental group was significantly lower than that in the control group (P0.05). The levels of serum soluble cell adhesion factor (s ICAM) -1) and endothelin (ET) 1 (ET) -1) in ESR (ESR) C reactive protein (CRP),) were significantly lower than those in control group (P0.05), and the level of (BUN), creatinine (Cr) in urea nitrogen was significantly lower than that in control group (P0.05). Conclusion the efficacy of fentinastar in the treatment of senile gout patients is better than that of phenylbromine Ma Long, and the renal function is less damaged.
【作者單位】： 綿陽市中心醫(yī)院風(fēng)濕免疫科;
【基金】：綿陽市痛風(fēng)及高尿酸血癥慢病管理系統(tǒng)構(gòu)建項目(14Q0063)
【分類號】：R589.7
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本文編號：2164683
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