本文選題：曲匹地爾 + 阿司匹林　； 參考：《山東醫(yī)藥》2017年46期

【摘要】：目的探討曲匹地爾對糖尿病小鼠血液中血小板活性的影響及其與阿司匹林相比的效果。方法選擇100只健康小鼠,10只為非模型對照組,90只通過腹腔注射四氧嘧啶建立糖尿病模型。取造模成功的60只小鼠,隨機分為生理鹽水組、阿司匹林組和曲匹地爾組各20只,分別給予生理鹽水10 m L、曲匹地爾和阿司匹林25 mg/kg10 m L灌胃,1次/d,連續(xù)3 d。3 d后,生理鹽水組、阿司匹林組和曲匹地爾組于灌胃后90、120和150 min時尾靜脈血取血,同法取非模型對照組尾靜脈血。制備富血小板血漿(PRP)及乏血小板血漿(PPP),用比濁法進行血小板聚集性測定,記錄血小板聚集率,計算血小板抑制率。結(jié)果生理鹽水組血小板聚集率高于非模型對照組,曲匹地爾組、阿司匹林組血小板聚集率均低于生理鹽水組(P均0.01)。曲匹地爾組、阿司匹林組血小板抑制率均高于生理鹽水組,曲匹地爾組血小板抑制率高于阿司匹林組(P均0.01)。90、120、150 min時曲匹地爾組血小板抑制率均高于阿司匹林組(P均0.01)。結(jié)論曲匹地爾與阿司匹林均能抑制糖尿病小鼠的血小板聚集,曲匹地爾抗血小板聚集效果強于阿司匹林,對血小板活化抑制時間更持久。
[Abstract]:Objective to investigate the effect of trapidil on platelet activity in blood of diabetic mice. Methods the diabetic model was established by intraperitoneal injection of alloxan in 90 healthy mice as control group (n = 90). Sixty mice were randomly divided into normal saline group (n = 20), aspirin group (n = 20) and trapidil group (n = 20). They were given normal saline 10 mL, trapidil and aspirin 25 mg/kg10 mL intragastrically for 3 days. Normal saline group, aspirin group and trapidil group were collected blood from caudal vein at 90120 and 150 min after gastric perfusion, and caudal vein blood from non-model control group by the same method. Platelet-rich plasma (PRP) and platelet-deficient plasma (PPP) were prepared, platelet aggregation was measured by turbidimetry, platelet aggregation rate was recorded and platelet inhibition rate was calculated. Results the platelet aggregation rate in normal saline group was higher than that in non-model control group, and the platelet aggregation rate in trapidil group and aspirin group was lower than that in normal saline group (P 0.01). The platelet inhibition rate of trapidil group and aspirin group was higher than that of normal saline group, and the platelet inhibition rate of trapidil group was higher than that of aspirin group at 90120150 min (P 0.01). Conclusion Trapidil and aspirin can inhibit platelet aggregation in diabetic mice.
【作者單位】： 大冶市第四人民醫(yī)院;湖北理工學(xué)院醫(yī)學(xué)院;
【基金】：湖北省腎臟疾病發(fā)生與干預(yù)重點實驗室基金項目(222/222205) 教育部留學(xué)生啟動資金(46-1) 湖北省重點學(xué)科湖北理工學(xué)院藥學(xué)學(xué)科資助
【分類號】：R587.1
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本文編號：2105524