本文選題：糖尿病 + 血管鈣化�。� 參考：《生理科學(xué)進(jìn)展》2017年05期

【摘要】：糖尿病血管鈣化是糖尿病嚴(yán)重的并發(fā)癥,這類患者病情相對復(fù)雜、各類并發(fā)癥多、治療難度大,呈現(xiàn)高發(fā)病率、高致殘率、高死亡率的形勢。新近的觀點認(rèn)為血管鈣化形成過程是中膜的血管平滑肌細(xì)胞(vascular smooth muscle cells,VSMCs)向成骨樣細(xì)胞表型轉(zhuǎn)變的一個骨發(fā)育類似的主動、可預(yù)防、可逆轉(zhuǎn)的可調(diào)控過程。既往研究著重于探討低氧誘導(dǎo)因子-1α(hypoxia inducible fator1,HIF-1α)與糖尿病血管新生的關(guān)系,而對于其與血管VSMCs成骨樣變的關(guān)聯(lián)未見綜述報道。基于此,本文將結(jié)合相關(guān)文獻(xiàn),從HIF-1α結(jié)構(gòu)及其功能、表達(dá)調(diào)控機制、阻斷劑應(yīng)用、HIF-1α與糖尿病VSMCs成骨樣變的關(guān)系四個方面做一綜述。
[Abstract]:Vascular calcification of diabetes mellitus is a serious complication of diabetes mellitus. This kind of patients' condition is relatively complex, many kinds of complications, the treatment is difficult, presents the situation of high incidence, high disability rate and high mortality. Recently, it is believed that the process of vascular calcification is a similar active, preventable and reversible process of bone development during the phenotypic transition of vascular smooth muscle cells (vascular smooth muscle cells) to osteoblast-like cells. Previous studies have focused on the relationship between hypoxia inducible factor-1 偽 (hypoxia inducible fator1HIF-1 偽) and diabetic angiogenesis. Based on this, this article will review the relationship between the structure and function of HIF-1 偽, the mechanism of expression regulation, and the relationship between HIF-1 偽 and osteogenesis of diabetic VSMCs.
【作者單位】： 中山大學(xué)孫逸仙紀(jì)念醫(yī)院心臟外科;中山大學(xué)附屬第五醫(yī)院消化內(nèi)科;
【基金】：廣東省自然科學(xué)基金(2016A030313295) 中山大學(xué)大型新興交叉學(xué)科資助項目(15ykjc17b)資助課題
【分類號】：R587.2

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