本文選題：甲狀腺功能亢進(jìn) + 骨代謝　； 參考：《山東醫(yī)藥》2017年30期

【摘要】：目的觀察甲狀腺功能亢進(jìn)(以下簡(jiǎn)稱(chēng)甲亢)患者骨密度及血清骨代謝指標(biāo)的變化,為甲亢患者骨質(zhì)疏松的早期診斷提供依據(jù)。方法選擇甲亢患者65例作為甲亢組、健康體檢者49例作為對(duì)照組。采用雙能X線骨密度儀檢測(cè)兩組腰椎1~4(L_1~L_4)和股骨近端(股骨頸、Wards三角、大粗隆)的骨密度。采集兩組空腹靜脈血,檢測(cè)血清骨代謝破骨細(xì)胞功能指標(biāo)β膠原特殊序列(β-CTX)、Ⅰ型前膠原羧基末端前肽(PⅠNP)、N端骨鈣素(N-MID)及間接反映破骨細(xì)胞活性的指標(biāo)骨源性堿性磷酸酶(ABAP)水平。結(jié)果甲亢組L_1~L_4、股骨頸、Wards三角、大粗隆骨密度均低于對(duì)照組(P均0.01),血清β-CTX、PⅠNP、N-MID及ABAP水平均高于對(duì)照組(P均0.05)。甲亢患者血清PⅠNP、N-MID、β-CTX均與各部位骨密度呈負(fù)相關(guān)(P均0.01)。結(jié)論甲亢患者多個(gè)部位的骨密度出現(xiàn)下降、血清骨代謝相關(guān)指標(biāo)明顯升高,且二者明顯相關(guān);動(dòng)態(tài)觀察血清骨代謝指標(biāo)有助于早期發(fā)現(xiàn)甲亢所致的骨質(zhì)疏松。
[Abstract]:Objective to observe the changes of bone mineral density (BMD) and serum bone metabolism in patients with hyperthyroidism (hereinafter referred to as hyperthyroidism) so as to provide evidence for the early diagnosis of osteoporosis in hyperthyroidism patients. Methods 65 patients with hyperthyroidism were selected as hyperthyroidism group and 49 healthy persons as control group. Dual energy X-ray absorptiometry was used to measure the bone mineral density (BMD) of the lumbar vertebrae (1D, 4L) and the proximal femur (the femoral neck, the great trochanter). Two groups of fasting venous blood were collected. Serum osteoclast function index 尾 -CTXN (尾 -CTX) and osteogenic alkaline phosphatase (ABAPP), an index of osteoclast activity, were measured. Results in the hyperthyroidism group, the bone mineral density (BMD) and the serum 尾 -CTX P 鈪，

本文編號(hào)：1985513