本文選題：烏司他丁 + 甲基強的松龍��； 參考：《中國地方病防治雜志》2017年02期

【摘要】：目的探討烏司他丁聯(lián)合甲基強的松龍治療急性吸入性有機氟中毒的臨床療效。方法抽取2011年7月至2015年12月在我院接受治療的急性吸入性有機氟中毒患者51例,隨機分組,對照組25例,觀察組26例,對照組靜脈滴注甲基強的松龍+生理鹽水治療,觀察組靜脈滴注烏司他丁+甲基強的松龍+生理鹽水治療,觀察比較兩組甲基強的松龍用量、療程、肺部滲出吸收時間、病死率、不良反應發(fā)生情況及治療前后患者中性粒細胞(PMN)、外周白細胞(WBC)、C反應蛋白(CRP)含量變化情況。結(jié)果觀察組甲基強的松龍用量(1417.05±916.35)mg、療程(6.35±1.64)d均小于對照組(5605.91±1641.58)mg、(11.33±6.32)d,差異具有統(tǒng)計學意義(P0.05);治療3d后、7d后,觀察組PMN、WBC、CRP均低于對照組,差異具有統(tǒng)計學意義(P0.05);觀察組肺部滲出吸收時間低于對照組,差異具有統(tǒng)計學意義(P0.05);對照組經(jīng)治療無效死亡2例,觀察組無死亡病例;不良反應發(fā)生率組間比較,差異無統(tǒng)計學意義(P0.05)。結(jié)論對急性吸入性有機氟中毒患者給予烏司他丁聯(lián)合甲基強的松龍治療,可有效改善患者中性粒細胞、外周白細胞及C反應蛋白水平,減少甲基強的松龍用量,縮短肺部滲出吸收及治療時間,且安全性高,值得臨床推廣應用。
[Abstract]:Objective to investigate the clinical effect of ulinastatin combined with methylprednisolone in the treatment of acute inhaled organic fluorosis. Methods from July 2011 to December 2015, 51 patients with acute inhaled organic fluorosis were randomly divided into control group (n = 25), observation group (n = 26) and control group (n = 26). In the observation group, the dosage of methylprednisolone, the course of treatment, the time of pulmonary exudation and the mortality were observed and compared by intravenous infusion of ulinastatin methylprednisolone with normal saline. The incidence of adverse reactions and the changes of the contents of neutrophil PMN and WBC C reactive protein (CRP) in patients before and after treatment. Results the dosage of methylprednisolone in the observation group was 1417.05 鹵916.35 mg / g, the course of treatment was 6.35 鹵1.64 / d, which was lower than that in the control group (5605.91 鹵1641.58) / mg / d (11.33 鹵6.32 / d), and the levels of CRP in the observation group were significantly lower than those in the control group (P < 0.05). The difference was statistically significant (P 0.05), the time of pulmonary exudation absorption in the observation group was lower than that in the control group, the difference was statistically significant (P 0.05); in the control group, there were 2 cases of ineffective death after treatment, and there were no cases of death in the observation group; the incidence rate of adverse reactions was compared between the two groups. The difference was not statistically significant (P 0.05). Conclusion Ulinastatin combined with methylprednisolone can effectively improve the levels of neutrophils, peripheral white blood cells and C-reactive protein and reduce the dosage of methylprednisolone in patients with acute inhaled organic fluorosis. It can shorten the time of pulmonary exudation absorption and treatment, and has high safety, so it is worth popularizing in clinic.
【作者單位】： 海南省人民醫(yī)院;
【基金】：海南省自然科學基金項目(811379)
【分類號】：R595

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