發(fā)布時(shí)間：2018-05-20 02:26

  本文選題：糖皮質(zhì)激素性骨質(zhì)疏松癥 + 系統(tǒng)性紅斑狼瘡��； 參考：《山東大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年05期

【摘要】：目的觀察骨代謝在糖皮質(zhì)激素性骨質(zhì)疏松癥(GIOP)進(jìn)展過程中與糖皮質(zhì)激素用藥時(shí)間的關(guān)系及變化規(guī)律,并依據(jù)骨代謝變化趨勢探討GIOP的防治策略。方法檢測應(yīng)用GC控制病情的系統(tǒng)紅斑狼瘡患者117例和健康人群21例骨代謝標(biāo)志物(β-CTX、T-P1NT、N-MIDOs),測定L1-4椎體骨密度。依據(jù)GC使用時(shí)間將患者分為7個(gè)亞組:Ⅰ組用藥1~6個(gè)月,Ⅱ組用藥7~12個(gè)月,Ⅲ組用藥13~18個(gè)月,Ⅳ組用藥19~24個(gè)月,Ⅴ組用藥25~30個(gè)月,Ⅵ組用藥31~36個(gè)月,Ⅶ組用藥36個(gè)月。結(jié)果Ⅰ組、Ⅱ組和Ⅲ組β-CTX較正常對照組明顯升高,差異有統(tǒng)計(jì)學(xué)意義(P0.05);Ⅵ組和Ⅶ組β-CTX較正常對照組明顯減低,差異有統(tǒng)計(jì)學(xué)意義(P0.05);Ⅳ組和Ⅴ組β-CTX較正常對照組無明顯差異(P0.05);應(yīng)用GC的各亞組T-P1NT、N-MIDOs均較正常對照組明顯減低,差異有統(tǒng)計(jì)學(xué)意義(P0.05);Ⅱ~Ⅶ組骨密度較正常對照組明顯減低,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 GIOP形成過程中,骨代謝是由高分解狀態(tài)向低分解低成骨低轉(zhuǎn)換狀態(tài)轉(zhuǎn)變。應(yīng)用GC 1~18個(gè)月的SLE患者骨代謝狀態(tài)處于高分解低成骨,應(yīng)用GC 30個(gè)月以上的患者骨代謝狀態(tài)處于低分解低成骨低轉(zhuǎn)換狀態(tài)。
[Abstract]:Objective to observe the relationship between bone metabolism and glucocorticoid administration time during the development of glucocorticoid-induced osteoporosis (GIOP) and discuss the prevention and treatment strategy of GIOP according to the trend of bone metabolism. Methods Bone mineral density (BMD) of L1-4 vertebrae was measured in 117 patients with systemic lupus erythematosus and 21 healthy controls. According to the time of GC, the patients were divided into seven subgroups: group 鈪，

本文編號：1912794