發(fā)布時間：2018-04-30 20:56

  本文選題：糖尿病 + 糖尿病急性并發(fā)癥��； 參考：《中風與神經疾病雜志》2017年09期

【摘要】：目的搜集糖尿病急性并發(fā)癥(Acute diabetic complications,ADC)患者的相關臨床指標,構建預測模型以評判繼發(fā)輕度認知功能障礙(Mild Cognitive Impairment,MCI)的預測價值,并驗證其應用性。方法 2014年4月~2016年4月期間湖北省中醫(yī)院、2015年1月~2016年4月期間湖北省中山醫(yī)院及武漢市中醫(yī)院收治的ADC患者為研究隊列,搜集相關臨床資料,對其進行為期1 y的隨訪以確認預后轉歸。依據(jù)隨訪結果預判繼發(fā)MCI風險的影響性指標,并分析繼發(fā)MCI時間窗以驗證應用性。結果 (1)Cox回歸分析顯示,ADC患者繼發(fā)MCI的風險模型由DM病程及HOMA-IR、NSE、IGF-1含量組成,其中IGF-1為保護性因素、其余為風險性因素;(2)DM病程≥13.349 y、HOMA-IR≥4.107 mmol/L*m IU/L、IGF-1107.420 ng/L的ADC患者,繼發(fā)MCI的時間窗更短,其中DM病程及IGF-1含量的臨界值指標具有更高的評判效能。結論 DM病程及HOMA-IR、NSE、IGF-1含量是ADC患者繼發(fā)MCI的獨立影響因素,且DM病程≥13.349 y、IGF-1107.420 ng/L為衡量ADC患者隨訪期內繼發(fā)MCI的臨界點。
[Abstract]:Objective to collect the clinical indexes of patients with acute diabetic complications of diabetes mellitus, and to establish a predictive model to evaluate the predictive value of mild-cognitive dysfunction (MHD) and verify its application. Methods from April 2014 to April 2016, ADC patients admitted from Hubei Zhongshan Hospital and Wuhan traditional Chinese Medicine Hospital from January 2015 to April 2016 were selected as the study cohort to collect the relevant clinical data. It was followed up for 1 y to confirm prognosis. According to the results of follow-up, the risk of secondary MCI was pre-determined and the secondary MCI time window was analyzed to verify its applicability. Results the risk model of secondary MCI was composed of DM course and HOMA-IRN NSEIGF-1 content, in which IGF-1 was a protective factor, and the rest was a risk factor for ADC whose course of disease 鈮，

本文編號：1826176