本文選題：-磷酸鞘氨醇 + -磷酸鞘氨醇受體��； 參考：《中國(guó)藥理學(xué)通報(bào)》2017年09期

【摘要】：1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)是細(xì)胞膜鞘磷脂代謝過(guò)程產(chǎn)生的一類(lèi)信號(hào)分子,在免疫系統(tǒng)中,與細(xì)胞膜表面的G蛋白偶聯(lián)受體S1P受體(S1P receptors,S1PRs)結(jié)合,通過(guò)相關(guān)炎癥信號(hào)通路,影響新生血管的形成。該文簡(jiǎn)述S1P及其受體通過(guò)細(xì)胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo)對(duì)類(lèi)風(fēng)濕關(guān)節(jié)炎、多發(fā)性硬化癥、結(jié)腸炎、系統(tǒng)性紅斑狼瘡等自身免疫性疾病微血管生成的影響,提出了S1P及其受體可能是治療自身免疫性疾病血管炎癥新的靶點(diǎn)。
[Abstract]:Sphingosine-1-phosphateate S1P) is a kind of signaling molecule produced by membrane sphingosine-1-phosphate phosphatidylcholine metabolism. In the immune system, it binds to the G protein coupled receptor S1P receptor S1P receptor S1PRs on the surface of the cell membrane and passes through the related inflammatory signaling pathway.Affect the formation of neovascularization.The effects of S1P and its receptors on microangiogenesis in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, colitis, systemic lupus erythematosus and so on were reviewed.It is suggested that S 1 P and S 1 P receptor may be a new target for the treatment of autoimmune disease vascular inflammation.
【作者單位】： 安徽中醫(yī)藥大學(xué)藥學(xué)院新安醫(yī)學(xué)教育部重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(No 81473400) 安徽中醫(yī)藥大學(xué)探索性研究性項(xiàng)目(No 2016ts072)
【分類(lèi)號(hào)】：R593.2
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本文編號(hào)：1754812