本文選題：骨鈣素　切入點(diǎn)：骨轉(zhuǎn)換標(biāo)記物　出處：《中國(guó)骨質(zhì)疏松雜志》2017年10期 　論文類型：期刊論文

【摘要】：目的比較原發(fā)性骨質(zhì)疏松癥(osteoporosis,OP)患者與對(duì)照人群血清骨鈣素(serum osteocalcin,s OC)水平。方法薈萃分析。檢索CENTRAL、Pub Med和CNKI等國(guó)內(nèi)外大型數(shù)據(jù)庫(kù),篩選關(guān)于骨質(zhì)疏松癥患者與對(duì)照人群s OC水平比較的病例對(duì)照研究,對(duì)納入研究進(jìn)行Meta分析,比較在不同性別及檢測(cè)不同s OC分子片段的情況下原發(fā)性骨質(zhì)疏松癥患者與對(duì)照人群體內(nèi)的s OC水平,以獲得相關(guān)臨床證據(jù)。結(jié)果共納入22項(xiàng)女性研究(包括2906人)以及13項(xiàng)男性研究(包括1338人)。絕經(jīng)后骨質(zhì)疏松(postmenopausal osteoporosis,PMO)組與對(duì)照組相比s OC水平明顯升高[95%置信區(qū)間(confidence interval,CI)為(1.59,5.84),P=0.0006],與PMO的高骨轉(zhuǎn)換率相符。而男性原發(fā)性O(shè)P發(fā)病機(jī)制不同于PMO,OP組與對(duì)照組相比s OC水平無(wú)統(tǒng)計(jì)學(xué)差異[95%CI(-2.31,3.98),P=0.60],此結(jié)果可能與男性原發(fā)性O(shè)P骨代謝狀態(tài)較為復(fù)雜且存在異質(zhì)性有關(guān)。結(jié)論 PMO患者s OC水平升高,結(jié)果對(duì)于PMO具有較高的輔助診斷價(jià)值。男性原發(fā)性O(shè)P患者s OC水平變化情況仍有爭(zhēng)議,綜合分析結(jié)果與對(duì)照組無(wú)差異。s OC檢測(cè)尚缺乏統(tǒng)一標(biāo)準(zhǔn),本研究結(jié)論尚需高質(zhì)量臨床研究進(jìn)一步驗(yàn)證。
[Abstract]:Objective to compare the serum osteocalcinins (OC) levels in patients with idiopathic osteoporosis (OPO) and control group. Methods Meta-analysis was used to search the large databases of CENTRALLPU Pub Med and CNKI at home and abroad. A case-control study on the comparison of OC levels between patients with osteoporosis and a control group was selected, and Meta analysis was performed on the inclusion study. To compare the level of OC between patients with primary osteoporosis and control group with different sex and different fragments of OC molecule. Results in 22 female studies (including 2, 906) and 13 male studies (including 1, 338) and postmenopausal osteoporosis, the levels of OC were significantly higher [95% confidence interval] than in the control group. Confidence intervalency is 1.59 / 5.84 / P 0.0006, which is consistent with the high bone turnover rate of PMO. The pathogenesis of primary op in men is different from that in the control group. There is no significant difference in the level of OC between the two groups [95CI-2.31 ~ 3.98 P0. 60]. This result may be more complicated and more complicated than that of male primary op bone metabolism. Conclusion the level of OC in patients with PMO is higher than that in controls. Results the changes of OC level in male patients with primary op were still controversial, and there was no difference between the results of comprehensive analysis and that of the control group. The conclusion of this study needs to be further verified by high-quality clinical studies.
【作者單位】： 中山大學(xué)附屬第三醫(yī)院脊柱外科;中山大學(xué)孫逸仙紀(jì)念醫(yī)院院長(zhǎng)辦公室;
【分類號(hào)】：R580

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