本文關(guān)鍵詞：2型糖尿病男性患者血清羧化不全骨鈣素水平與其認知功能受損的相關(guān)性研究　出處：《中國現(xiàn)代醫(yī)學雜志》2016年03期 　論文類型：期刊論文

  更多相關(guān)文章： 型糖尿病 男性 羧化不全骨鈣素 認知

【摘要】：目的探討2型糖尿病(T2DM)男性患者血清羧化不全骨鈣素(uc OC)水平與其認知功能受損的相關(guān)性。方法選取唐山工人醫(yī)院住院的T2DM男性患者71例作為病例組,同時從醫(yī)院體檢中心選取健康男性68例作為對照組,收集以上所有研究對象的一般資料[年齡、教育程度、體重指數(shù)(BMI)及病程]及臨床生化指標[空腹血糖(FPG)、糖化血紅蛋白(Hb A1c)、總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)及低密度脂蛋白(LDL)]。用酶聯(lián)免疫吸附法(ELISA)測定血清uc OC水平,并進行認知功能量表(RBANS)(包括即時記憶、視覺廣度、言語功能、注意力和延遲記憶)評分。比較以上兩組認知評分是否存在差異;將T2DM組按uc OC中位數(shù)水平分為高uc OC組和低uc OC組,對兩組的認知評分進行比較。用單因素相關(guān)及多元逐步回歸分析uc OC與認知評分之間的相關(guān)性。結(jié)果 1T2DM組較對照組TC、TG及FPG水平升高,HDL、uc OC水平降低(P0.05),兩組年齡、教育、BMI及LDL差異無統(tǒng)計學意義(P0.05);2與對照組比較,T2DM組RBANS量表總分、即時記憶、視覺廣度、注意力及延遲記憶評分降低(P0.05),兩組言語功能評分差異無統(tǒng)計學意義(P0.05);3在T2DM組中,低uc OC組較高uc OC組RBANS量表總分、即時記憶、言語功能、注意力及延遲記憶評分降低(P0.05);4經(jīng)多元逐步回歸分析發(fā)現(xiàn)在T2DM組中:uc OC與Hb A1c呈負相關(guān)(P0.05),并且uc OC與RBANS量表總分、即時記憶、言語功能、注意力及延遲記憶評分呈正相關(guān)(P0.05)。結(jié)論T2DM男性患者血清uc OC水平降低可能是其認知功能受損的危險因素之一。
[Abstract]:Objective to investigate the type 2 diabetes mellitus (T2DM) in male patients with serum undercarboxylated Osteocalcin (UC OC) and the correlation between the level of cognitive impairment. Methods the Tangshan workers' hospital T2DM 71 cases of male patients as case group, at the same time from the hospital medical center selected healthy male 68 cases as control group, collecting all the research object the general data of age, education level, body mass index (BMI) and the course of disease and clinical biochemical indicators [] fasting blood glucose (FPG), glycosylated hemoglobin (Hb A1c), total cholesterol (TC), three glycerol (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) with. Enzyme linked immunosorbent assay (ELISA) determination of serum UC OC level and cognitive function scale (RBANS) (including instant memory, visual span, speech function, attention and delayed memory score). The comparison between the two groups whether there are differences in cognitive score; T2DM group according to the UC OC in The number of water divided into high UC group and low OC UC OC group, to compare the two groups of the cognitive score. Using single factor correlation and multiple stepwise regression analysis of correlation between UC OC and cognitive score. Results in the 1T2DM group than in the control group TC, TG and FPG increased, HDL level, UC reduced the level of OC (P0.05) two, age, education, BMI and LDL had no significant difference (P0.05; 2) compared with the control group, T2DM group, RBANS total score, immediate memory, visual span, attention and delayed memory score was lower (P0.05), the two groups had no statistically significant difference in verbal function score (P0.05); 3 in T2DM group in the low UC group OC UC group OC RBANS high score, immediate memory, verbal function, attention and delayed memory score was lower (P0.05); 4 by stepwise multiple regression analysis showed that in the T2DM group: UC OC was negatively correlated with Hb A1c (P0.05), UC and OC and RBANS scores. Immediate memory, verbal function, attention There was a positive correlation between the delayed memory score and the delayed memory score (P0.05). Conclusion the decrease of UC OC level in the serum of T2DM male patients may be one of the risk factors for the impairment of cognitive function.

【作者單位】： 河北醫(yī)科大學唐山工人醫(yī)院內(nèi)分泌科;
【基金】：河北省自然科學基金(No:H2015105083)
【分類號】：R587.2
【正文快照】： 近年來2型糖尿病(type 2 diabetes mellitus,T2DM)與認知功能障礙的關(guān)系越來越被人們關(guān)注。研究表明,T2DM患者出現(xiàn)認知功能障礙(如老年癡呆、血管性癡呆等)的危險性是正常人的1.5~2.0倍[1],但是其確切的機制還不是很清楚。骨鈣素是成骨細胞分泌的一種非膠原蛋白質(zhì),目前動物實

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