【摘要】：目的探討腎移植受者術(shù)前甘油三酯(TG)代謝對(duì)其移植腎早期功能(EGF)恢復(fù)的影響。方法回顧性分析2011年1月-2014年12月170例在解放軍309醫(yī)院接受活體腎移植受者的臨床資料,經(jīng)排除標(biāo)準(zhǔn)篩選后最終納入154例受者,其中男124例,女30例,年齡31.9±8.4歲。根據(jù)受者術(shù)前TG水平分為T(mén)G正常組(0.40TG≤1.70mmol/L,n=107)及TG異常組(TG1.70mmol/L或需服用降脂藥控制血脂者,n=47),觀察兩組患者中移植腎功能恢復(fù)不佳(PEGF)、腎功能延遲恢復(fù)(DGF)和腎功能緩慢恢復(fù)(SGF)的發(fā)生率,進(jìn)一步比較移植腎功能順利恢復(fù)(IGF)的兩組受者術(shù)后3、7及30d的肌酐(Scr)水平。繪制以TG為診斷指標(biāo)的ROC曲線,以獲得預(yù)測(cè)腎移植術(shù)后發(fā)生PEGF、SGF、DGF風(fēng)險(xiǎn)的最佳TG值。結(jié)果與TG正常組相比,TG異常組的受者術(shù)后PEGF及DGF的發(fā)病率較高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。IGF的受者中,TG異常組術(shù)后7、30d的Scr值高于TG正常組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。術(shù)前TG預(yù)測(cè)PEGF、SGF及DGF的ROC曲線下面積(AUC)分別為0.774、0.704、0.818,均明顯大于機(jī)會(huì)參考下面積(P0.05),最佳臨界值均為1.37mmol/L。結(jié)論受者術(shù)前TG代謝異常對(duì)移植腎早期功能恢復(fù)可能具有負(fù)性影響。術(shù)前受者TG在正常高值時(shí)(1.37mmol/L),其發(fā)生PEGF、SGF和DGF的風(fēng)險(xiǎn)便已增加。
[Abstract]:Objective to investigate the effect of triglyceride (TG) metabolism on early functional (EGF) recovery in renal transplantation recipients. Methods the clinical data of 170 recipients of live kidney transplantation in PLA 309 Hospital from January 2011 to December 2014 were retrospectively analyzed. 154 recipients, including 124 males and 30 females, aged 31.9 鹵8.4 years, were selected by exclusion criteria. According to the preoperative TG level, the recipients were divided into two groups: normal TG group (0.40TG 鈮，

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