本文選題：左卡尼汀 + 維持性血液透析��； 參考：《中國老年學(xué)雜志》2017年19期

【摘要】：目的探析左卡尼汀(L-CN)對接受維持性血液透析(MHD)治療的終末期腎病(ESRD)老年患者的微炎癥及貧血、營養(yǎng)不良狀態(tài)的影響。方法 MHD治療的54例ESRD老年患者隨機(jī)分成觀察組(L-CN治療)和對照組(無L-CN治療),分別為26和28例。比較兩組基線資料、炎性因子、營養(yǎng)及貧血改善指標(biāo)的表達(dá)水平。結(jié)果治療前兩組各炎性指標(biāo),包括血清白細(xì)胞介素(IL)-6,IL-8,超敏C反應(yīng)蛋白(hs-CRP),腫瘤壞死因子(TNF)-α與脂蛋白[La(a)]水平無顯著差異(P0.05);治療后,對照組各炎性指標(biāo)水平與治療前無顯著差異(P0.05),而觀察組各炎性指標(biāo)水平較對照組與治療前均明顯降低(P0.05)。治療前兩組營養(yǎng)及貧血指標(biāo),包括血漿白蛋白(Alb)、血細(xì)胞比容(Hct)、血紅蛋白(Hb)、轉(zhuǎn)鐵蛋白(TRF)、血漿總蛋白(TP)及前白蛋白(PAB)的表達(dá)水平無顯著差異(P0.05);治療后,對照組各指標(biāo)較治療前無顯著差異(P0.05),而觀察組各指標(biāo)較對照組及治療前均顯著升高(P0.05)。結(jié)論 L-CN治療不但可以顯著改善MHD老年ESRD患者的微炎癥反應(yīng),還可以糾正腎性貧血和營養(yǎng)不良的狀態(tài)。
[Abstract]:Objective to investigate the effects of L-CNL on microinflammation, anemia and malnutrition in elderly patients with end-stage renal disease (ESRD) treated with maintenance hemodialysis (MHD). Methods 54 elderly patients with ESRD treated with MHD were randomly divided into two groups: observation group (n = 26) and control group (n = 28). The expression of baseline data, inflammatory factors, nutrition and anemia were compared between the two groups. Results there was no significant difference in the levels of serum IL-8, hs-CRP, TNF- 偽 and lipoprotein between the two groups before treatment, including IL-8, hs-CRP, TNF- 偽 and lipoprotein (Lahua-), after treatment, there was no significant difference between the two groups (P 0.05). There was no significant difference in the levels of inflammatory indexes between the control group and the control group before treatment (P 0.05), but the levels of each inflammatory index in the observation group were significantly lower than those in the control group and before treatment (P 0.05). Before treatment, there was no significant difference in the levels of nutritional and anemia indexes between the two groups, including the expression of plasma albumin Albbumin, HCT, HBC, TRFT, TPTP and PAB.After treatment, there was no significant difference between the two groups (P 0.05), and after treatment, there was no significant difference between the two groups in the expression levels of TRFF, TPTP and PAB.After the treatment, there was no significant difference in the expression levels between the two groups. There was no significant difference in the indexes of the control group compared with that before treatment, but the indexes of the observation group were significantly higher than those of the control group and before treatment. Conclusion the treatment of L-CN can not only improve the microinflammation in MHD elderly patients with ESRD, but also correct renal anemia and malnutrition.
【作者單位】： 海南省農(nóng)墾總醫(yī)院腎內(nèi)科;
【基金】：海南省科學(xué)技術(shù)廳應(yīng)用技術(shù)研發(fā)與示范推廣專項項目(No.ZDXM2015085)
【分類號】：R692.5

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