本文選題：糖調(diào)節(jié)受損 + 良性前列腺增生�。� 參考：《實(shí)用醫(yī)學(xué)雜志》2016年04期

【摘要】：目的:檢測糖調(diào)節(jié)受損(IGR)合并良性前列腺增生(BPH)患者胰島素水平、胰島素生長因子-1(IGF-1)、胰島素生長因子結(jié)合蛋白-3(IGFBP-3)等指標(biāo),旨在探討IGF-1、IGFBP-3等指標(biāo)與前列腺體積(PV)的相關(guān)性。方法 :選取年齡≥50歲的BPH患者109例,根據(jù)OGTT結(jié)果分為糖耐量正常(NGT)組56例、空腹血糖受損(IFG)組14例及糖耐量減低(IGT)組39例;測量各組人群常規(guī)生化指標(biāo)、前列腺增生指標(biāo)以及血清IGF-1、IGFBP-3濃度等。結(jié)果:3組患者血脂、同型半胱氨酸、胱抑素C、空腹胰島素(FINS)、糖化血紅蛋白、IGF-1、IGFBP-3比較均無統(tǒng)計(jì)學(xué)差異(P0.05);3組患者PV、前列腺特異抗原、生活質(zhì)量評(píng)分、國際前列腺癥狀評(píng)分比較無統(tǒng)計(jì)學(xué)差異(P0.05)。IFG組空腹血糖、胰島素抵抗指數(shù)(HOMA-IR)高于NGT組(P′0.017)和IGT組(P′0.017);IGT組2 h血糖、2 h胰島素高于NGT組(P′0.017)及IFG組(P′0.017);多元逐步回歸分析,PV與FINS呈正相關(guān),與IGF-1、IGFBP-3無關(guān)。結(jié)論:高血清胰島素水平是IGR合并BPH患者前列腺增生進(jìn)展的危險(xiǎn)因素,血清IGF-1、IGFBP-3與BPH無相關(guān)性,需進(jìn)一步研究闡明IGF-1、IGFBP-3在BPH的作用。
[Abstract]:Objective: to investigate the correlation between IGF-1IGFBP-3 and prostatic volume (PVV) in patients with impaired glucose regulation (IGR) and benign prostatic hyperplasia (BPH). Methods: 109 BPH patients aged more than 50 years were divided into normal glucose tolerance group (n = 56), fasting blood glucose impaired group (n = 14) and impaired glucose tolerance group (n = 39) according to the results of OGTT. Prostatic hyperplasia index and serum IGF-1 IGFBP-3 concentration. Results there was no significant difference in blood lipids, homocysteine, cystatin C, fasting insulin and IGF-1IGFBP-3 between the three groups. There was no statistical difference in the international prostate symptom score (P 0.05). The fasting blood glucose in the IFG group was higher than that in the control group. Insulin resistance index (HOMA-IRI) was higher than that of NGT group (P 0.017), IGT group (P 0.017) and IGT group (P < 0.017) and IFG group (P < 0.017). Multivariate stepwise regression analysis showed that PV was positively correlated with FINS, but had no correlation with IGF-1IGFBP-3. Conclusion: high serum insulin level is a risk factor for the progression of BPH in IGR patients with BPH. There is no correlation between IGF-1IGFBP-3 and BPH. It is necessary to further study the role of IGF-1IGFBP-3 in BPH.
【作者單位】： 承德醫(yī)學(xué)院附屬醫(yī)院老年病科;承德醫(yī)學(xué)院附屬醫(yī)院檢驗(yàn)科;
【基金】：河北省醫(yī)學(xué)科學(xué)研究重點(diǎn)課題計(jì)劃(編號(hào):ZL20140234) 2016年政府資助臨床醫(yī)學(xué)優(yōu)秀人才培養(yǎng)和基礎(chǔ)課題研究項(xiàng)目(編號(hào):361008)
【分類號(hào)】：R697.3

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