本文選題：糖尿病　切入點：勃起功能障礙　出處：《中國糖尿病雜志》2017年06期

【摘要】：目的觀察糖尿病勃起功能障礙患者血清瘦素的表達(dá)水平,并探討其臨床意義。方法選取男性糖尿病患者255例,根據(jù)國際勃起功能指數(shù)-5(IIEF-5)評分將研究對象分為勃起功能障礙(ED)組(IIEF-5≤21分)137例和單純糖尿病組(DM,IIEF-521)118例,另選體檢健康男性(NC)100名。收集各組臨床資料,檢測血清瘦素和性激素水平。糖尿病ED患者血清瘦素水平與其他指標(biāo)的相關(guān)性采用Pearson相關(guān)性分析和多元逐步回歸分析。結(jié)果ED組FPG、FIns、2 hPG、HbA_1c、TC、HDL-C、HOMA-IR高于DM組和NC組(P0.05或P0.01);與NC組比較,ED組和DM組總睪酮(TT)[(11.19±4.12)vs(18.51±4.66)vs(14.74±4.71)nmol/L]、LH[(4.53±2.64)vs(13.81±2.69)vs(8.46±2.97)U/L]、FSH[(10.20±4.12)vs(20.68±4.11)vs(13.21±3.58)U/L]及瘦素[(7.04±5.36)vs(19.45±9.15)vs(12.06±6.47)ng/ml]水平升高,SHBG[(56.19±14.00)vs(38.25±10.12)vs(46.21±12.44)nmol/L]水平降低(P0.05或P0.01);Pearson相關(guān)性分析顯示,血清瘦素水平與BMI、FIns、HOMA-IR呈正相關(guān),與TT呈負(fù)相關(guān)(P0.05或P0.01);多元逐步回歸分析顯示,BMI和TT為ED患者血清瘦素水平的影響因素(P=0.000)。結(jié)論糖尿病ED患者血清瘦素水平升高。BMI和TT可能是糖尿病ED患者血清瘦素水平的影響因素。
[Abstract]:Objective to observe the level of serum leptin in patients with diabetic erectile dysfunction and to explore its clinical significance.Methods 255 male patients with diabetes mellitus were divided into two groups according to the International erectile function Index (IIEF-5) score: erectile dysfunction (EDV) group (IIEF-5 鈮，

本文編號：1716396