本文選題：非肌層浸潤性膀胱癌　切入點：經(jīng)尿道膀胱腫瘤切除術　出處：《山西醫(yī)科大學》2016年碩士論文　論文類型：學位論文

【摘要】：目的:利用meta分析的優(yōu)勢,更加高效客觀的評價綠激光選擇性膀胱腫瘤汽化術(PVBT)與經(jīng)尿道膀胱腫瘤切除術(TURBT)治療非肌層浸潤性膀胱腫瘤(NMIBC)的術后療效及手術的安全性。方法:選取發(fā)表于國內(nèi)外核心期刊上的2006~2015年的文獻,對比PVBT與TURBT兩種術式治療的NMIBC的臨床對照試驗,嚴格按照納入排除標準提取相關指標數(shù)據(jù),并應用Meta分析的方法評價手術的安全性及術后療效。結果:最終共有14篇文獻符合納入標準,總研究樣本量1680例,PVBT組761例,TURBT組919例。Meta分析結果:PVBT組比TURBT組術后復發(fā)率低[OR 0.39,95%CI0.27-0.56,P0.0001]。PVBT組與TURBT組兩種術式手術時間無明顯差別[p0.05]。PVBT組術后住院時間比TURBT組短[SMD-2.53 d,95%CI-3.61-(-1.44)d,P0.0001]。PVBT組手術出血量比TURBT組少[SMD-18.16 ml,95%CI-19.65-(-16.66)ml,P0.0001]。PVBT組術后尿管留置時間比TURBT組短[SMD-2.60 d,95%CI-3.42-(-1.77)d,P0.0001]。PVBT組術后膀胱沖洗時間比TURBT組短[SMD-1.23,95%CI-1.35-(-1.12),P0.0001]。PVBT組手術并發(fā)癥發(fā)生率比TURBT低[OR 0.06,95%CI 0.03-0.12,p0.0001]。結論:對于NMIBC的治療,PVBT術較TURBT術不會增加手術時間,并且表現(xiàn)出在手術安全性指標較經(jīng)典的TURBT術式有一定優(yōu)勢,更為重要的是,PVBT術可能會有助于降低NMIBC術后的復發(fā)率。
[Abstract]:Objective: to utilize the advantage of meta analysis, To evaluate the efficacy and safety of green laser selective vaporization of bladder tumor (PVBT) and transurethral resection of bladder tumor (TURBT) in the treatment of non-muscular invasive bladder tumor. The literature from 2006 to 2015 in internal and external core journals, The clinical controlled trials of NMIBC treated with PVBT and TURBT were compared, and the relevant index data were extracted strictly according to the inclusive exclusion criteria. Meta analysis was used to evaluate the safety and efficacy of the operation. Results: a total of 14 articles met the inclusion criteria. The results of Meta-analysis showed that the recurrence rate of TURBT group was lower than that of TURBT group [OR 0.3995 CI0.27-0.56P 0.0001] .There was no significant difference between PVBT group and TURBT group. The postoperative hospitalization time of PVBT group was shorter than that of TURBT group [SMD-2.53 d95CI-3.61-1.44d#en0# P0.0001]. The postoperative urinary catheter retention time in the PVBT group was shorter than that in the TURBT group [SMD-2.60 d95CI-3.42-1.77dP0.0001]. The postoperative bladder irrigation time in the PVBT group was shorter than that in the TURBT group [SMD-1.2395CI-1.35-P0.0001]. The incidence of postoperative complications in the PVBT group was lower than that in the TURBT group [OR 0.0695 CI 0.03-0.12p 0.0001]. Conclusion: the duration of postoperative bladder irrigation in the PVBT group is not longer than that in the TURBT group [SMD-1.2395CI-1.35-P0.0001]. The incidence of postoperative complications in the PVBT group is lower than that in the TURBT group [OR 0.0695 CI 0.03-0.12p 0.0001]. The results also showed that there were some advantages in the safety index of operation compared with the classical TURBT operation, and more importantly, it might be helpful to reduce the recurrence rate of NMIBC.
【學位授予單位】：山西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R737.14

【相似文獻】

相關期刊論文 前10條

1 吳小鵬,陸曙炎,蔡雷銘,鄒建綱,周忠興,關乃富,陳仰之,陳靜;膀胱腫瘤細胞多藥耐藥檢測在浸潤性膀胱腫瘤治療中的應用[J];東南大學學報(醫(yī)學版);2005年06期

2 羅斌;;經(jīng)尿道綠激光汽化術治療非肌層浸潤性膀胱腫瘤[J];中國實用醫(yī)藥;2010年35期

3 劉萃龍;趙豫波;郭建軍;關維民;張勇建;歐陽昀;周國明;于春杰;;三種腔鏡技術應用于治療非浸潤性膀胱腫瘤的療效、安全性比較[J];武警醫(yī)學;2013年03期

4 于惠元;;多發(fā)性非浸潤性膀胱腫瘤的腔內(nèi)化學療法[J];國外醫(yī)學參考資料.外科學分冊;1974年01期

5 ;細胞核形態(tài)參數(shù)在表淺及浸潤性膀胱腫瘤中的預后價值[J];國外醫(yī)學.泌尿系統(tǒng)分冊;1996年04期

6 劉海濤;夏術階;孫曉文;韓邦e，

本文編號：1628635