【摘要】：目的:觀察電針內(nèi)關(guān)穴對(duì)體外循環(huán)下行瓣膜置換術(shù)患者的心肌保護(hù)作用。方法:擬行心臟瓣膜置換術(shù)的風(fēng)濕性心臟病患者50例,根據(jù)美國麻醉醫(yī)師協(xié)會(huì)(ASA)分級(jí)為Ⅱ~Ⅲ級(jí),紐約心臟病協(xié)會(huì)心功能分級(jí)Ⅱ~Ⅲ級(jí),隨機(jī)分為觀察組和對(duì)照組,每組25例。兩組患者均采用相同的麻醉及體外循環(huán)灌注技術(shù)。觀察組于術(shù)前30min電針刺激雙側(cè)內(nèi)關(guān)穴直至手術(shù)結(jié)束。分別于主動(dòng)脈阻斷前(T1),主動(dòng)脈開放后15min(T2)、30min(T3)、6h(T4)、24h(T5)5個(gè)時(shí)點(diǎn)采集中心靜脈血,檢測(cè)血清丙二醛(MDA)、超氧化物歧化酶(SOD)、心肌鈣蛋白I(cTnI)濃度,并記錄心臟復(fù)跳及術(shù)后血管活性藥物使用總量等情況。結(jié)果:與主動(dòng)脈阻斷前比較,兩組患者在主動(dòng)脈開放后各時(shí)間點(diǎn)MDA、cTnI明顯升高(均P0.05),SOD明顯下降(P0.05);與對(duì)照組比較,在T3~T5時(shí)間點(diǎn),觀察組血清MDA、cTnI明顯低于對(duì)照組(均P0.05),SOD則高于對(duì)照組(P0.05);血管活性藥物使用量明顯減少(P0.05)。結(jié)論:電針內(nèi)關(guān)穴可減輕氧化應(yīng)激損傷,對(duì)缺血再灌注心肌具有保護(hù)作用。
[Abstract]:Objective: to observe the myocardial protective effect of electroacupuncture at Neiguan point on patients undergoing valve replacement under cardiopulmonary bypass. Methods: fifty patients with rheumatic heart disease undergoing cardiac valve replacement were randomly divided into observation group and control group according to the (ASA) grade of the American Association of Anesthesiologists and the cardiac function grade 鈪，

本文編號(hào)：2412674