發(fā)布時(shí)間：2018-10-23 09:42

【摘要】：目的:通過Meta分析評(píng)價(jià)丙泊酚對(duì)肝臟缺血再灌注損傷的保護(hù)作用。 方法:按照制定的檢索策略系統(tǒng)檢索Pub Med、EMBASE、Web of Knowledge、TheCochane Library、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫、萬方全文數(shù)據(jù)庫、維普中文科技期刊數(shù)據(jù)庫、中國(guó)知網(wǎng)，檢索日期截止到2014年2月28日，限中英文語種，并計(jì)算機(jī)或手工查閱研究中引用的參考文獻(xiàn)。按照制定的納入和排除標(biāo)準(zhǔn)，納入所有研究丙泊酚麻醉對(duì)肝門阻斷的肝臟切除術(shù)成年病人的肝缺血再灌注影響的隨機(jī)對(duì)照試驗(yàn)，對(duì)獲得2篇以上相關(guān)的全文文獻(xiàn)應(yīng)用RevMan5.2軟件進(jìn)行Meta分析。 結(jié)果:共檢索到21篇符合納入標(biāo)準(zhǔn)的文獻(xiàn)，共計(jì)1097例病例，其中試驗(yàn)組686例，對(duì)照組511例。主要的結(jié)局指標(biāo)：肝門阻斷末到再開放15min(T1) SOD、MDA、ALT、AST，肝門再開放30-45min(T2) SOD、MDA。術(shù)后第1天(T3) ALT、AST，術(shù)后第3-4天(T4) ALT、AST。Meta分析結(jié)果如下，T1SOD：MD為15.08nU/ml，95%CI為(10.81,19.36) nmol/l，P0.05；T2SOD：MD為24.20nU/ml，95%CI為(17.86,30.53) nmol/l，P0.05；T1MDA：MD為-5.73nmol/l，95%CI為(-7.29,-4.16) nmol/l，P0.05；T2MDA：MD為-5.81nmol/l，95%CI為(-7.84，-2.71) nmol/l，P0.05；T1ALT：MD為-24.46IU/L，95%CI為(-30.86,-18.04)IU/L，P0.05；T3ALT：MD為-31.49IU/L，95%CI為(-36.73,-26.26) IU/L，P0.05；T4ALT：MD為-0.77IU/L，95%CI為(-2.63,1.10) IU/L，P=0.42；T1AST:MD為-23.85IU/L，95%CI為(-29.78,-17.93) IU/L，P0.05；T3AST：MD為-5.85IU/L，95%CI為(-29.14,17.45) IU/L，P=0.62；T4ALT：MD為-2.32IU/L，，95%CI為(-7.29,2.65) IU/L，P=0.36。 結(jié)論：丙泊酚對(duì)肝門阻斷肝切除術(shù)的肝缺血再灌注損傷有一定的保護(hù)作用。
[Abstract]:Objective: to evaluate the protective effect of propofol on hepatic ischemia reperfusion injury by Meta analysis. Methods: according to the retrieval strategy, Pub Med,EMBASE,Web of Knowledge,TheCochane Library, Chinese Biomedical Literature Database, Wanfang Full-text Database, Weipu Chinese Sci-tech Journals Database, Chinese Journal of Science and Technology, China knowledge Network were searched. The retrieval date was as of February 28, 2014. Limited to Chinese and English languages, and computer or manual reference cited in the study. All randomized controlled trials to study the effects of propofol anesthesia on hepatic ischemia-reperfusion in adult patients undergoing hepatectomy with hilar occlusion were included in accordance with established inclusion and exclusion criteria. RevMan5.2 software was used to analyze more than 2 related articles in Meta. Results: a total of 21 articles, including 686 cases in the experimental group and 511 cases in the control group, were found. Main outcome measures: end of hilar occlusion to reopening 15min (T1) SOD,MDA,ALT,AST, 30-45min (T2) SOD,MDA. 鏈悗絎

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