發(fā)布時間：2018-06-30 10:28

  本文選題：腰硬聯(lián)合麻醉 + 去氧腎上腺素　； 參考：《四川大學學報(醫(yī)學版)》2017年06期

【摘要】：目的研究去氧腎上腺素和間羥胺在預防剖宮產術腰硬聯(lián)合麻醉后低血壓的半數有效劑量(ED50),并計算二者等效比。方法 103例單胎足月孕擬行擇期剖宮產術患者分為去氧腎上腺素組(41例)和間羥胺組(62例)。常規(guī)行腰硬聯(lián)合麻醉,麻醉完成后即刻開始泵注試驗用藥,去氧腎上腺素和間羥胺初始質量濃度分別為1.0mg/100mL和2.0mg/100mL,固定輸注速率為100mL/h,試驗采用序貫法決定下一病例藥物劑量,兩種藥物劑量梯度為0.05mg。觀察術中血壓、不良反應及胎兒臍血血氣分析結果。以術中觀察期間患者收縮壓低于基礎值80%或90mmHg(1mmHg=0.133kPa),定為該試驗劑量無效,患者收縮壓≥基礎值,則視為該試驗劑量有效。采用Probit回歸分析測量試驗藥物的ED50及其95%可信區(qū)間(CI)。結果在試驗條件下,維持剖宮產術腰硬聯(lián)合麻醉后血壓于基礎值水平所需去氧腎上腺素和間羥胺ED50分別為1.221 7mg(95%CI為1.099 1~1.593 7)和2.824 0mg(95%CI為2.658 9~3.433 6),兩種藥物等效比值為1∶2.3。術中兩種藥物副作用及兩組胎兒臍血血氣分析比較差異無統(tǒng)計學意義(P0.05)。結論以100mL/h持續(xù)泵注,維持產婦腰硬聯(lián)合麻醉后血壓于基礎水平所需的去氧腎上腺素和間羥胺ED50分別為1.221 7mg/100mL和2.824 0mg/100mL,二者等效比值為1∶2.3。
[Abstract]:Objective to study the median effective dose (ED50) of deoxyadrenaline and hydroxylamine in the prevention of caesarean section after combined spinal and epidural anesthesia, and to calculate the equivalent ratio of two cases. Methods 103 cases of single term single term pregnancy were divided into 41 cases (41 cases) and intervertebral hydroxylamine group (62 cases). The initial mass concentration of adrenaline and hydroxylamine was 1.0mg/100mL and 2.0mg/100mL, respectively, the initial mass concentration of adrenaline and hydroxylamine was 1.0mg/100mL and 2.0mg/100mL, and the fixed infusion rate was 100mL/h. The sequential method was used to determine the dosage of the next case. The two drug dose gradient was 0.05mg., the adverse reaction and fetal umbilical blood gas analysis results were observed. When the systolic pressure was lower than the base value of 80% or 90mmHg (1mmHg=0.133kPa) during the intraoperative observation, the test dose was invalid and the systolic pressure of the patient was more than the base value, which was considered to be the effective dose. Probit regression analysis was used to measure the ED50 of the test drug and its 95% confidence interval (CI). Deoxyadrenaline and hydroxylamine ED50 were 1.221 7Mg (95%CI 1.099 1~1.593 7) and 2.824 0mg (95%CI 2.658 9~3.433 6), respectively. The equivalent ratio of two kinds of drugs was 1: 2.3., and two groups of fetal umbilical blood gas analysis were not statistically significant (P0.05). The conclusion was 100. ML/h continued to pump, to maintain the essential level of deoxyadrenaline and interhydroxylamine ED50, 1.221 7mg/100mL and 2.824 0mg/100mL respectively, and the equivalent ratio of 1: 2.3. to the basic level of the parturient after the combined spinal epidural anesthesia.
【作者單位】： 四川大學華西第二醫(yī)院麻醉科;
【分類號】：R614

【相似文獻】

相關期刊論文 前10條

1 ;澳大利亞發(fā)布局部使用去氧腎上腺素導致肺水腫的風險[J];中國藥物評價;2012年02期

2 付云明;羅贏;刀蓮萍;;去氧腎上腺素和麻黃堿預防剖宮產母嬰影響的分析[J];中國當代醫(yī)藥;2012年07期

3 許正才;;去氧腎上腺素和麻黃素對剖宮產產婦低血壓和新生兒安全性的影響[J];海峽藥學;2012年07期

4 王遠;陳雪華;;去氧腎上腺素在硬-腰聯(lián)合麻醉引起低血壓的老年患者中的應用[J];中國現代醫(yī)學雜志;2011年19期

5 余燕云;王猛;王群;;麻黃堿與去氧腎上腺素對胎心率的影響[J];江蘇醫(yī)藥;2012年16期

6 唐培佳;譚冠先;梁勇升;徐秀月;;預防性持續(xù)靜脈輸注去氧腎上腺素預防腰麻剖宮產術縮宮素對產婦血流動力學的影響[J];醫(yī)學理論與實踐;2013年11期

7 張曉坤;王U嗗，

本文編號：2085971