本文選題：瑞芬太尼 + 痛覺過敏��； 參考：《中國新藥雜志》2015年24期

【摘要】：目的:瑞芬太尼(RF)誘發(fā)的阿片源性痛覺過敏抑制了其在臨床麻醉的使用。脊髓星形膠質(zhì)細(xì)胞的活化可能與其相關(guān)。本實(shí)驗(yàn)探討RF誘發(fā)痛覺過敏與星形膠質(zhì)細(xì)胞活化的關(guān)系,同時(shí)研究電針治療是否從機(jī)制上抑制痛敏的發(fā)生。方法:SD大鼠72只隨機(jī)分為4組,每組均作切口痛模型:I組(切口痛對(duì)照組)尾靜脈泵注生理鹽水;R+I組(RF痛敏組)尾靜脈泵注RF 0.8μg·kg-1;R+T組(電針治療組)泵注RF前30 min開始電針治療直至術(shù)畢;R+F組(假治療組):泵注RF前以穴位電針刺激直至術(shù)畢。分別在術(shù)前24 h、RF輸注后4,12,24和48 h測(cè)量各實(shí)驗(yàn)組大鼠的熱刺激縮足潛伏期(PWTL)和機(jī)械刺激縮足閾(PWMT)。按不同時(shí)間點(diǎn)(4,24和48 h)處死實(shí)驗(yàn)大鼠,并取腰段脊髓測(cè)GFAP的濃度。結(jié)果:1行為學(xué)指標(biāo):RF痛敏組機(jī)械痛閾與熱痛閾均高于切口痛對(duì)照組(P0.05),電針治療組低于RF痛敏組(P0.05)。2標(biāo)本GFAP表達(dá):RF痛敏組明顯高于切口痛對(duì)照組(P0.05),電針治療組低于RF痛敏組(P0.05)。結(jié)論:實(shí)驗(yàn)證實(shí)了脊髓星形膠質(zhì)細(xì)胞活化與瑞芬太尼誘導(dǎo)的痛覺過敏密切相關(guān),電針治療可以抑制其活化,從而預(yù)防瑞芬太尼導(dǎo)致的痛覺過敏,給臨床的多模式鎮(zhèn)痛提供理論依據(jù)。
[Abstract]:Objective: remifentanil (RF)-induced opioid hyperalgesia inhibits the use of anaesthesia. The activation of spinal astrocytes may be associated with it. This study was to investigate the relationship between RF induced hyperalgesia and astrocyte activation. Methods 72 Sprague-Dawley rats were randomly divided into 4 groups. Each group was given incision pain model: 1: 1 group (incision pain control group), caudal vein pump injection of normal saline Ri group (RF pain sensitive group) caudal vein pump injection RF 0.8 渭 g kg ~ (-1) R T group (electroacupuncture group) 30 min before pump injection of RF acupuncture treatment until the end of surgery R F Group (sham treatment group): before pump RF injection, acupoint electroacupuncture was used until the end of operation. The latent period of thermal stimulation (PWTL) and mechanical stimulation of foot contraction threshold (PWMT) were measured 24 and 48 hours after RF infusion at 24 hours before operation in each experimental group. The experimental rats were killed at different time points (4 h and 48 h), and the concentration of GFAP in lumbar spinal cord was measured. Results the mechanical pain threshold and thermal pain threshold of the 1: 1 behavioral index group were higher than those of the incision pain control group (P0.05), and the GFAP expression of GFAP in the electroacupuncture group was significantly higher than that in the incision pain control group (P0.05), and the expression of GFAP in the electroacupuncture group was significantly higher than that in the incision pain control group (P0.05), and that in the electroacupuncture group was lower than that in the RF pain sensitive group (P0.05). Conclusion: activation of astrocytes in spinal cord is closely related to remifentanil induced hyperalgesia. Electroacupuncture can inhibit the activation of remifentanil and prevent remifentanil induced hyperalgesia. To provide a theoretical basis for clinical multi-mode analgesia.
【作者單位】： 安徽醫(yī)科大學(xué)附屬省立醫(yī)院麻醉科;
【基金】：安徽省衛(wèi)生廳中醫(yī)藥科研課題項(xiàng)目(2012zy45)
【分類號(hào)】：R614

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本文編號(hào)：2081977