發(fā)布時(shí)間：2018-06-23 06:13

  本文選題：帕瑞昔布 + 瑞芬太尼��； 參考：《中外醫(yī)學(xué)研究》2016年10期

【摘要】：目的:研究分析帕瑞昔布在瑞芬太尼全身麻醉手術(shù)中的臨床效果,為后期的瑞芬太尼全身麻醉手術(shù)提供相應(yīng)的借鑒以及參考。方法:選取2013年12月-2015年2月筆者所在醫(yī)院行全身麻醉手術(shù)的患者50例作為研究對(duì)象,將其列為帕瑞昔布鎮(zhèn)痛組,進(jìn)行帕瑞昔布鎮(zhèn)痛。同時(shí)選取同期進(jìn)行全身麻醉手術(shù)的患者50例作為生理鹽水鎮(zhèn)痛組,生理鹽水鎮(zhèn)痛組進(jìn)行等容量生理鹽水鎮(zhèn)痛。在完成手術(shù)后對(duì)患者的術(shù)后疼痛、圍術(shù)期炎性水平等進(jìn)行分析研究,對(duì)比兩組患者的效果。結(jié)果:拔管后,帕瑞昔布鎮(zhèn)痛組患者各時(shí)間段VAS疼痛評(píng)分均明顯低于生理鹽水鎮(zhèn)痛組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05);鎮(zhèn)痛后帕瑞昔布鎮(zhèn)痛組患者的IL-6水平、IL-8水平均明顯低于生理鹽水鎮(zhèn)痛組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05),IL-10水平明顯高于生理鹽水鎮(zhèn)痛組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);兩組患者氣管導(dǎo)管拔除前的評(píng)分比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05);拔管后10 min評(píng)分情況,生理鹽水鎮(zhèn)痛組躁動(dòng)評(píng)分均明顯高于帕瑞昔布鎮(zhèn)痛組,鎮(zhèn)靜評(píng)分明顯低于帕瑞昔布鎮(zhèn)痛組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:使用帕瑞昔布可以促使瑞芬太尼全身麻醉患者的術(shù)后疼痛感受有效的降低,可以促使圍術(shù)期炎癥因子的水平進(jìn)一步降低,說明帕瑞昔布在瑞芬太尼全身麻醉手術(shù)中具有非常顯著的臨床效果,值得進(jìn)一步推廣使用。
[Abstract]:Objective: to study the clinical effect of pareoxib in remifentanil general anesthesia, and to provide reference for remifentanil general anesthesia. Methods: 50 patients undergoing general anesthesia operation in our hospital from December 2013 to February 2015 were selected as the study objects, and they were classified as the pareoxib analgesia group for paroxib analgesia. At the same time, 50 patients undergoing general anesthesia were selected as normal saline analgesia group and saline analgesia group. The postoperative pain and perioperative inflammatory level were analyzed and compared between the two groups. Results: after extubation, the VAS pain scores of patients in the pareoxib analgesia group were significantly lower than those in the saline analgesia group. The levels of IL-6 and IL-8 in pareoxib analgesia group were significantly lower than those in saline analgesia group (P0.05), and the level of IL-10 was significantly higher than that in saline analgesia group. The difference was statistically significant (P0.05); there was no significant difference between the two groups before trachea extubation (P0.05); 10 min after extubation, the restlessness score of saline analgesia group was significantly higher than that of pareoxib analgesia group. Sedation score was significantly lower than that of pareoxib analgesia group, the difference was statistically significant (P0.05). Conclusion: the use of pareoxib can effectively reduce postoperative pain perception in patients with remifentanil general anesthesia, and further decrease the level of inflammatory factors in perioperative period. The results suggest that pareoxib has a significant clinical effect in remifentanil general anesthesia, and it is worth further popularizing.
【作者單位】： 張家界市人民醫(yī)院;
【分類號(hào)】：R614

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