氟比洛芬酯對老年胸外傷手術患者鎮(zhèn)痛中應激反應及相關蛋白的影響
發(fā)布時間:2018-02-09 03:44
本文關鍵詞: 氟比洛芬酯 麻醉 鎮(zhèn)痛 應激 出處:《中國老年學雜志》2017年04期 論文類型:期刊論文
【摘要】:目的探討氟比洛芬酯在胸外傷手術中對老年患者應激反應及相關蛋白的影響。方法 60例美國麻醉師協(xié)會(ASA)Ⅰ~Ⅱ級需行胸外傷手術的老年患者隨機分為兩組各30例,對照組進行常規(guī)麻醉,觀察組麻醉誘導前給予氟比洛芬酯,記錄兩組血壓、心率(HR)、血氧等應激情況,并對鎮(zhèn)痛效果及內皮素(ET)-1的水平變化進行對比。結果觀察組患者平均動脈壓(MAP)、HR、血氧飽和度(SpO_2)水平均明顯優(yōu)于對照組(P0.05)。觀察組甲腎上腺素(NE)及ET-1水平低于對照組,但差異不明顯(P0.05)。觀察組患者術后1、6、12 h視覺模擬疼痛評分均明顯小于對照組(P0.05)。觀察組發(fā)生嗜睡、惡心嘔吐等不良反應發(fā)生率,明顯少于對照組,且住院時間明顯少于對照組(P0.05)。結論氟比洛芬酯能夠有效減輕麻醉誘導引發(fā)的注射痛,減輕蘇醒期的應激反應,減少不良反應的發(fā)生,縮短住院時間。
[Abstract]:Objective to investigate the effects of flurbiprofen ester on stress response and related proteins in elderly patients undergoing thoracic trauma surgery. Methods Sixty elderly patients undergoing thoracic trauma surgery were randomly divided into two groups (30 cases each). Routine anesthesia was performed in the control group, and flurbiprofen ester was given to the observation group before anesthesia induction. The blood pressure, heart rate, HRN and blood oxygen stress were recorded in the two groups. The effect of analgesia and the level of endothelin (et) 1 were compared. Results the mean arterial pressure (MAPH) and blood oxygen saturation (SPO _ 2) in the observation group were significantly higher than those in the control group (P 0.05), and the levels of NE and ET-1 in the observation group were lower than those in the control group. The visual analogue pain score of the observation group was significantly lower than that of the control group (P 0.05). The incidence of somnolence, nausea and vomiting in the observation group was significantly lower than that in the control group. Conclusion flurbiprofen ester can effectively reduce the injection pain induced by anesthesia, reduce the stress reaction during the recovery period, reduce the occurrence of adverse reactions and shorten the hospital stay.
【作者單位】: 天津市西青醫(yī)院胸心外科;武警后勤學院科研部;
【分類號】:R614
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