【摘要】：目的本研究利用自體濃縮生長(zhǎng)因子(CGF)膜修復(fù)口腔黏膜組織缺損,觀察、探討其促進(jìn)軟組織愈合、減少瘢痕的效果,評(píng)價(jià)CGF膜應(yīng)用于口腔黏膜組織缺損修復(fù)的臨床意義,并為口腔黏膜組織缺損的治療提供新的思路和方法。方法選擇并收集寧夏醫(yī)科大學(xué)總醫(yī)院口腔頜面外科病房2015年3月至2016年11月收治的因手術(shù)切除造成口腔黏膜組織缺損的患者,隨機(jī)分組,實(shí)驗(yàn)組利用自體CGF膜修復(fù)缺損創(chuàng)面后碘仿紗條敷料反包扎固定;對(duì)照組直接運(yùn)用碘仿紗條敷料反包扎覆蓋創(chuàng)面進(jìn)行同期對(duì)照。隨訪術(shù)后1周、2周、3周、1月、2月、3月口腔黏膜缺損區(qū)生長(zhǎng)情況,拍攝照片,運(yùn)用Image-Pro Plus(IPP)圖像分析軟件計(jì)算缺損區(qū)域愈合面積率,記錄創(chuàng)面愈合時(shí)間,采用視覺模擬量表(VAS)測(cè)評(píng)患者的主觀感受,用溫哥華瘢痕量表(VSS)中文版測(cè)評(píng)術(shù)后3月瘢痕形成情況,并進(jìn)行統(tǒng)計(jì)分析。結(jié)果自2015年3月至2016年11月收集的口腔黏膜組織缺損患者42例,失訪3例,39例納入研究,隨機(jī)分為實(shí)驗(yàn)組19例,對(duì)照組20例。1.對(duì)實(shí)驗(yàn)組與對(duì)照組術(shù)后2周、3周、1月時(shí)創(chuàng)面愈合率進(jìn)行統(tǒng)計(jì)學(xué)分析,差異具有統(tǒng)計(jì)學(xué)意義。2.對(duì)實(shí)驗(yàn)組與對(duì)照組術(shù)后1周、2周、3周、1月時(shí)VAS評(píng)分進(jìn)行統(tǒng)計(jì)學(xué)分析,顯示均有統(tǒng)計(jì)學(xué)差異。3.對(duì)實(shí)驗(yàn)組與對(duì)照組術(shù)后3月時(shí)VSS評(píng)分進(jìn)行統(tǒng)計(jì)學(xué)分析,顯示差異具有統(tǒng)計(jì)學(xué)意義。結(jié)論1.CGF膜可以用于口腔黏膜組織缺損的修復(fù)。2.應(yīng)用CGF膜修復(fù)口腔黏膜組織缺損創(chuàng)面,可縮短創(chuàng)面愈合時(shí)間、減輕術(shù)后不適感、減少術(shù)后瘢痕的形成。3.CGF膜取自自體靜脈血,獲取方便快捷,適宜臨床推廣。
[Abstract]:Objective to observe the effect of autologous concentrated growth factor (CGF) membrane on repairing oral mucous membrane tissue defect, to explore the effect of promoting soft tissue healing and reducing scar, and to evaluate the clinical significance of CGF membrane in the repair of oral mucous membrane tissue defect. It also provides a new idea and method for the treatment of oral mucous membrane tissue defect. Methods from March 2015 to November 2016, patients with oral and maxillofacial defects caused by surgical resection were randomly divided into two groups. In the experimental group, iodoform gauze dressing was fixed with iodoform gauze dressing after repairing the defect wound with autologous CGF membrane. The control group was directly covered with iodoform gauze dressing for the same period. 1 week, 2 weeks, 3 weeks, 1 month, 2 months and 3 months after follow-up, the growth of oral mucous membrane defect area was taken, the healing area rate of defect area was calculated by Image-Pro Plus (IPP) image analysis software, and the wound healing time was recorded. The subjective feelings of the patients were measured by visual simulation scale (VAS), and the scar formation was evaluated by Vancouver scar scale (VSS) in Chinese version, and the statistical analysis was carried out. Results from March 2015 to November 2016, 42 patients with oral mucosal tissue defect were collected, 3 of them lost follow-up, and 39 of them were included in the study. They were randomly divided into experimental group (n = 19) and control group (n = 20). The wound healing rate of the experimental group and the control group at 2 weeks, 3 weeks and 1 month after operation were statistically analyzed, and the difference was statistically significant. 2. The VAS scores of the experimental group and the control group at 1 week, 2 weeks, 3 weeks and 1 month after operation were statistically analyzed, and there was significant difference between the experimental group and the control group at 1 week, 2 weeks, 3 weeks and 1 month after operation. The VSS score of the experimental group and the control group at 3 months after operation was statistically analyzed, and the difference was statistically significant. Conclusion 1.CGF membrane can be used to repair oral mucous membrane defects. 2. The application of CGF membrane to repair oral mucous membrane defect can shorten the wound healing time, reduce the discomfort after operation and reduce the formation of scar after operation. 3. CGF membrane is taken from autologous venous blood, which is convenient and rapid, and is suitable for clinical promotion.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R782

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 于鑫瑋;高承志;;自體靜脈血在不同離心條件下特定生長(zhǎng)因子成分測(cè)定與分析性研究[J];中國(guó)醫(yī)藥導(dǎo)刊;2016年09期

2 王超;王佐林;;CGF與脂肪干細(xì)胞聯(lián)合應(yīng)用修復(fù)大鼠全層皮膚缺損的研究[J];口腔頜面外科雜志;2016年04期

3 孫曉芳;謝挺;;創(chuàng)面修復(fù)中生長(zhǎng)因子研究及臨床干預(yù)新進(jìn)展[J];創(chuàng)傷外科雜志;2016年03期

4 孫玉環(huán);何冬梅;楊馳;孫寧寧;蔡怡華;王麗珍;張萍;;自體濃縮生長(zhǎng)因子膜對(duì)山羊髁突軟骨缺損的修復(fù)作用[J];中國(guó)口腔頜面外科雜志;2014年03期

5 龔博林;方圓文;;濃縮生長(zhǎng)因子治療復(fù)發(fā)性口腔潰瘍的療效觀察[J];中國(guó)老年保健醫(yī)學(xué);2013年06期

6 胡以信;袁杰;鄒勇;郭力;劉兵;;富血小板血漿在促進(jìn)兔燙傷創(chuàng)面愈合中bFGF VEGF的表達(dá)及意義[J];重慶醫(yī)學(xué);2013年35期

7 王天祥;鄒高峰;李超;翟孝雅;石昌艷;;CGF中VEGF、TGF-β1含量測(cè)定及其對(duì)軟組織創(chuàng)傷愈合影響的實(shí)驗(yàn)研究[J];中外醫(yī)學(xué)研究;2013年10期

8 柳宏志;鄒高峰;王天祥;李超;;濃縮生長(zhǎng)因子促進(jìn)犬軟組織損傷修復(fù)的實(shí)驗(yàn)研究[J];口腔頜面外科雜志;2013年01期

9 李嘉朋;陳巨峰;符志鋒;冼淡;莫礎(chǔ)嘉;;應(yīng)用異體脫細(xì)胞真皮基質(zhì)修復(fù)口腔黏膜缺損82例分析[J];中國(guó)口腔頜面外科雜志;2006年05期

10 郭振榮;脫細(xì)胞異種真皮基質(zhì)作為修復(fù)材料大有可為[J];中華整形外科雜志;2002年05期

相關(guān)碩士學(xué)位論文 前2條

1 王國(guó)光;富自體濃縮生長(zhǎng)因子纖維蛋白凝膠/膜形態(tài)學(xué)觀察及皮下充填實(shí)驗(yàn)研究[D];河北醫(yī)科大學(xué);2014年

2 齊喜娟;富自體濃縮生長(zhǎng)因子纖維蛋白凝膠（液體）活性因子及其含量分析[D];河北醫(yī)科大學(xué);2014年

，

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