【摘要】：目的:分析先天缺牙和唇/腭裂綜合征相關蛋白--TP63蛋白的相互作用分子,并對其生物學功能進行分析。方法:利用生物信息學數(shù)據(jù)庫(STRING)分析和預測TP63蛋白的相互作用蛋白。在DAVID數(shù)據(jù)庫對相互作用蛋白的生物學功能進行分析。結果:對STRING數(shù)據(jù)庫預測的TP63蛋白50個相互作用蛋白的生物學功能分析顯示,TP63相互作用分子主要參與對細胞增殖和凋亡的調節(jié)。結論:生物信息學分析初步揭示了TP63蛋白的相互作用網(wǎng)絡及其生物學功能。
[Abstract]:Aim: to analyze the interaction molecules of TP63 protein associated with congenital tooth deficiency and lip / cleft palate syndrome, and to analyze its biological function. Methods: the interaction protein of TP63 protein was analyzed and predicted by bioinformatics database (STRING). The biological function of interacting proteins was analyzed in DAVID database. Results: the biological function analysis of 50 interaction proteins of TP63 protein predicted by STRING database showed that TP63 interaction molecules were mainly involved in the regulation of cell proliferation and apoptosis. Conclusion: bioinformatics analysis revealed the interaction network and biological function of TP63 protein.
【作者單位】： 湖北醫(yī)藥學院附屬隨州醫(yī)院.隨州市中心醫(yī)院口腔科;武漢大學口腔醫(yī)學院湖北省口腔基礎醫(yī)學重點實驗室-省部共建國家重點實驗室培育基地;
【基金】：國家自然科學基金(編號:81470727;81501750) 湖北省口腔基礎醫(yī)學重點實驗室-省部共建國家重點實驗室培育基地開放研究基金(編號:201402)
【分類號】：R782.2
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本文編號：2202052