【摘要】：目的：探討不同數(shù)目磨牙缺失對幼年大鼠認(rèn)知能力的影響。方法：健康幼年大鼠60只隨機(jī)分成3、6、9、12顆磨牙缺失組、麻醉對照、正常對照6組。在造模后1周,采用Morris水迷宮系統(tǒng)測試各組大鼠學(xué)習(xí)記憶能力,每周1次,連續(xù)6周。結(jié)果：9顆、12顆磨牙缺失組間大鼠游泳平均逃逸潛伏期(the swimming average escape latency,SAEL)無明顯差異,但均顯著高于其它4組(P0.001)；6顆磨牙缺失組大鼠與3顆磨牙缺失組、麻醉組及正常對照組間SAEL比較有差異(P0.05)；3顆磨牙缺失組、麻醉組及正常對照組組間SAEL比較均無顯著性差異(P0.05)。各磨牙缺失組大鼠隨著磨牙缺失數(shù)目的增多tP/tT值有逐漸下降趨勢,9顆、12顆磨牙缺失組間比較無差異(P0.05)與其余各組間比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),但3顆磨牙缺失組與正常組及麻醉組間tP/tT值無明顯差異(P0.05),其他各磨牙缺失組與正常組及麻醉組間tP/tT值均有差異(P0.05)。不同數(shù)目磨牙缺失的四組大鼠與麻醉組和正常組在造模前及造模后六周中體重變化組間比較無差異(P0.05)結(jié)論：較多數(shù)目磨牙缺失會對幼年大鼠的認(rèn)知能力造成不同程度的損傷,而個別磨牙缺失對大鼠的認(rèn)知功能無顯著性影響。
[Abstract]:Objective: to investigate the effect of different number of molar loss on cognitive ability of young rats. Methods: sixty healthy young rats were randomly divided into 3 groups (n = 12), anesthetic control group (n = 6) and normal control group (n = 6). Morris water maze system was used to test the ability of learning and memory once a week for 6 weeks. Results there was no significant difference in the average escape latency of (the swimming average escape latencies (the swimming average escape latencies) between the two groups, but they were significantly higher than those in the other four groups (P0. 001). There was significant difference in SAEL between anesthetic group and normal control group (P0.05). There was no significant difference in SAEL between anesthetic group and normal control group (P0.05). With the increase of the number of molar missing, the tP/tT value of each molar missing group decreased gradually. There was no significant difference between 9 and 12 molar missing groups (P0.05) compared with the other groups (P0.05), but the three molar missing group and the other groups had no significant difference (P0.05). There was no significant difference in tP/tT value between normal group and anesthetic group (P0.05), but there was significant difference in tP/tT value between other molar missing group and normal group and anesthesia group (P0.05). There was no significant difference in body weight changes between the four groups with different number of molar defects and the anesthetic group and the normal group (P0.05). Conclusion: the cognitive ability of the young rats was damaged by more number of molar loss than that of the anesthetic group and the normal group (P0.05). However, the loss of individual molars had no significant effect on the cognitive function of rats.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R783.4

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 劉洪臣,王東勝,劉秀芳,張慶詩;咀嚼運(yùn)動前后腦血流變化的研究[J];口腔頜面修復(fù)學(xué)雜志;2003年02期

2 韓杰,趙香玉;心理療法配合激光照射治療顳下頜關(guān)節(jié)紊亂病的療效觀察[J];黑龍江醫(yī)藥科學(xué);2005年01期

3 丁玎;洪震;;老年性癡呆和輕度認(rèn)知功能障礙的流行病學(xué)研究進(jìn)展[J];中國臨床神經(jīng)科學(xué);2013年01期

4 岳珍珠;黃立;周曉林;;口香糖咀嚼的腦機(jī)制[J];心理科學(xué);2006年05期

5 林允信;許昌泰;;阿爾茨海默病流行病學(xué)和相關(guān)基因研究現(xiàn)狀[J];醫(yī)學(xué)綜述;2012年11期

6 丁稱心;;單側(cè)下頜第一磨牙缺失對咀嚼效率的影響研究[J];中國現(xiàn)代醫(yī)生;2009年33期

7 楊敬源;黃文ng;楊星;汪俊華;雷明玉;張娜;顏克英;;貴陽市城區(qū)老年人認(rèn)知功能障礙及影響因素分析[J];中國公共衛(wèi)生;2008年10期

8 張作記,馮學(xué)泉,戚厚興,林立;學(xué)習(xí)與記憶——腦與行為研究的前沿[J];中國行為醫(yī)學(xué)科學(xué);2005年01期

9 劉傳軍;李善剛;郭延奎;高慧英;;缺氧缺血性腦損傷對新生大鼠大腦皮質(zhì)突觸發(fā)育的追蹤研究[J];中國行為醫(yī)學(xué)科學(xué);2006年05期

10 王艷,蘇敏,田東萍;長期硒缺乏對大鼠子代海馬CA3區(qū)突觸結(jié)構(gòu)參數(shù)的影響[J];中華病理學(xué)雜志;2005年05期

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