本文選題：慢性牙周炎 + 齦溝液�。� 參考：《中國老年學雜志》2017年01期

【摘要】：目的探究老年慢性牙周炎患者齦溝液(GCF)中基質金屬蛋白酶(MMP)-1和MMP組織抑制物(TIMP)-1水平與齦下刮治和根面平整術效果和牙周組織狀況的關系。方法 53例齦下刮治和根面平整術治療的老年慢性牙周炎患者為觀察組,49例行健康檢查的老年人為對照組。對比治療前后兩組牙周指標菌斑指數(shù)(PI)、探針出血(BOP)、探針深度(PD)、附著喪失(AL)及GCF中MMP-1和TIMP-1水平差異變化;分析觀察組GCF中MMP-1、TIMP-1與PI的相關性。結果兩組治療前牙周指標及GCF中MMP-1、TIMP-1水平差異均顯著,且治療后觀察組牙周指標及GCF中MMP-1、TIMP-1水平與對照組及治療前差異顯著,觀察組GCF中MMP-1(r=0.493,P0.001)及TIMP-1(r=0.515,P0.001)與PI呈正相關。結論老年慢性牙周炎患者經齦下刮治和根面平整術治療后效果顯著,牙周組織現(xiàn)狀好轉改善,GCF中MMP-1、TIMP-1水平下降明顯,炎癥反應逐漸消失。
[Abstract]:Objective to investigate the relationship between the levels of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of MMP (TIMP- 1) in gingival crevicular fluid (GCF) of elderly patients with chronic periodontitis and the effect of subgingival curettage, root surface leveling and periodontal tissue status. Methods 53 cases of senile chronic periodontitis treated by subgingival curettage and root surface leveling were treated as control group (n = 49). The levels of MMP-1 and TIMP-1 in GCF and MMP-1 and TIMP-1 in GCF were compared before and after treatment, and the correlation between TIMP-1 and Pi in GCF was analyzed. Results there were significant differences between the two groups in the periodontal indexes and the levels of MMP-1 and TIMP-1 in GCF, and the levels of MMP-1 and TIMP-1 in GCF in the observation group were significantly higher than those in the control group and before treatment. There was a positive correlation between the levels of MMP-1 and TIMP-1p0.001 in GCF and TIMP-1r0.515P0.001 in the observation group. Conclusion the effect of subgingival curettage and root surface leveling in elderly patients with chronic periodontitis was remarkable. The improvement of periodontal tissue and improvement of the level of MMP-1 and TIMP-1 in GCF decreased significantly, and the inflammatory reaction gradually disappeared.
【作者單位】： 新疆生產建設兵團醫(yī)院口腔科;
【分類號】：R781.42

【參考文獻】

相關期刊論文 前9條

1 喬麗;;基礎治療對慢性牙周炎臨床療效和齦下牙周致病菌的影響觀察[J];中國現(xiàn)代藥物應用;2016年04期

2 范云;陳棟;葉新;余方方;李瑋;;吸煙對慢性牙周炎患者齦溝液及牙齦組織中β防御素2、3的影響[J];上�？谇会t(yī)學;2015年06期

3 王璐;周美璐;許春姣;邱喜麗;徐文華;吳凱悅;池毓坦;;牙周炎基礎治療前、后齦溝液中SFRP1總量的變化[J];上�？谇会t(yī)學;2015年06期

4 張芳;陳燕;蔡哲;路東升;李婧;李宜磊;舒駿;郭麗麗;王曉霞;;補腎養(yǎng)陰清火法治療慢性牙周炎的臨床療效和對齦溝液中IL-1β、IL-6的影響[J];中華中醫(yī)藥雜志;2015年12期

5 王妙妍;章錦才;周磊;陳廣盛;;慢性牙周炎對口腔及胃幽門螺桿菌感染率的影響[J];中國老年學雜志;2015年20期

6 林俏霞;;牙周基礎治療對慢性牙周炎伴2型糖尿病患者炎癥反應及糖代謝的影響[J];中國醫(yī)學工程;2015年07期

7 丁紅柳;葛學軍;曹艷;;甲硝唑牙周炎控緩藥膜對慢性牙周病齦溝液基質金屬蛋白酶-8表達的影響[J];中國藥物與臨床;2014年11期

8 董愛芬;;基礎治療與牙周手術對慢性牙周炎患者血清腫瘤壞死因子及齦溝液中病原菌的影響[J];中華醫(yī)院感染學雜志;2013年13期

9 洛偉昕;佟Q，

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