發(fā)布時間：2018-05-29 10:27

  本文選題：嬰幼兒血管瘤 + 普萘洛爾�。� 參考：《上海交通大學》2014年碩士論文

【摘要】：目的：目前對于普萘洛爾與類固醇激素治療頜面部嬰幼兒血管瘤（infantilehemangiomas，IHs）療效與安全性的問題上仍存在爭議。國內(nèi)外已經(jīng)有許多學者對于兩種藥物做過臨床對比研究。本文旨在收集并總結相關文獻，為臨床合理用藥提供詢證醫(yī)學證據(jù)。 材料和方法：計算機檢索Medline數(shù)據(jù)庫、Pubmed數(shù)據(jù)庫、Cochrane圖書館臨床對照研究資料庫及萬方數(shù)據(jù)庫、中國知網(wǎng)數(shù)據(jù)庫。搜索國內(nèi)外2013年9月以前發(fā)表的單純應用普萘洛爾及單純應用類固醇激素治療血管瘤對照研究，對所納入的研究提取有效數(shù)據(jù)，并運用Cochrane協(xié)作網(wǎng)提供的RevMan5.0軟件對數(shù)據(jù)進行統(tǒng)計學分析。 結果：按照已制定的檢索策略，，納入單純應用普萘洛爾及單純應用類固醇激素治療血管瘤對照研究9篇。采用固定效應模型進行分析，結果顯示普萘洛爾組在療效方面優(yōu)于類固醇激素組（RR=1.94,95%CI：1.40,2.69，P0.0001）差異有統(tǒng)計學意義。對藥物不良反應做統(tǒng)計學分析，采用固定效應模型進行分析，結果顯示普萘洛爾組在藥物不良反應方面優(yōu)于類固醇激素組（RR=0.42,95%CI：0.28，0.64，P0.0001）差異有統(tǒng)計學意義。在治療IHs并發(fā)潰瘍方面，暫無兩類藥物的隨機對照研究，不過通過總結納入的3篇普萘洛爾治療IHs并發(fā)潰瘍的研究，證明普萘洛爾較其他傳統(tǒng)治療方式，在治療IHs并發(fā)潰瘍方面有一定優(yōu)勢。 結論：與單純應用類固醇激素相比，普萘洛爾可以作為一線藥物治療嬰幼兒血管瘤。
[Abstract]:Objective: to investigate the efficacy and safety of propranolol and steroid in the treatment of infantile hemangiomatosis (IHs) in infants with maxillofacial hemangioma. Many scholars at home and abroad have done clinical comparative research on the two drugs. The purpose of this paper is to collect and summarize the relevant literature and provide evidence for rational use of drugs in clinic. Materials and methods: the Medline database was searched by computer. To search for the control study on the treatment of hemangioma with propranolol alone and steroid hormone alone published before September 2013, and to extract valid data from the included study, The data are analyzed statistically by using RevMan5.0 software provided by Cochrane Cooperative Network. Results: according to the search strategy, 9 articles were included in the control study of propranolol alone and steroid hormone alone in the treatment of hemangioma. The results showed that the effect of propranolol group was better than that of steroid hormone group. The adverse drug reactions were analyzed statistically and the fixed effect model was used. The results showed that the propranolol group was better than the steroid hormone group in the adverse drug reaction. The difference was statistically significant (P 0.0001). In the treatment of IHs with ulcers, there is no randomized controlled study of two kinds of drugs. However, by summarizing the three studies of propranolol in the treatment of IHs complicated with ulcers, it is proved that propranolol is more effective than other traditional treatment methods. It has some advantages in the treatment of IHs complicated with ulcers. Conclusion: propranolol can be used as a first-line drug in the treatment of infantile hemangioma.
【學位授予單位】：上海交通大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R739.81

【參考文獻】

相關期刊論文 前10條

1 熊師;羅俊;周立軍;王曦瑯;陶利娟;楊慧玲;;普萘洛爾在嬰幼兒眼部血管瘤中的應用[J];國際眼科雜志;2012年01期

2 吳杉英;王彪;熊舒原;莊福連;黃循鐳;王美水;黃祖根;鄭厚兵;;普萘洛爾治療增生期嬰幼兒血管瘤的臨床研究[J];中國美容醫(yī)學;2010年11期

3 李喜;;普萘洛爾口服治療嬰幼兒血管瘤的效果觀察[J];山東醫(yī)藥;2011年34期

4 張志愿;口腔頜面部血管瘤、血管畸形的治療選擇[J];上�？谇会t(yī)學;2000年04期

5 鄭家偉;王延安;周國瑜;竺涵光;葉為民;張志愿;;頭頸部血管瘤治療適應證的探討[J];上�？谇会t(yī)學;2007年04期

6 紀影暢;蔡湘娜;許宏權;李宏生;肖洋;李宇;;普萘洛爾治療嬰幼兒面部血管瘤的初步觀察[J];汕頭大學醫(yī)學院學報;2012年01期

7 金英姬;金哲虎;崔笑怡;金玉姬;;普萘洛爾口服治療嬰幼兒血管瘤的臨床觀察[J];中國皮膚性病學雜志;2011年09期

8 楊俊，李國光;Meta－analysis在流行病學應用中的進展[J];中國公共衛(wèi)生;1995年06期

9 鄭家偉;周琴;王延安;范新東;周國瑜;秦中平;趙吉宏;王緒凱;趙怡芳;;口腔頜面部血管瘤治療指南[J];中國口腔頜面外科雜志;2011年01期

10 徐勇;Meta分析常見資料類型及統(tǒng)計分析方法[J];中華預防醫(yī)學雜志;1994年05期

本文編號：1950539