本文選題：慢病毒 + 載體�。� 參考：《中國(guó)矯形外科雜志》2014年14期

【摘要】：基因工程技術(shù)治療骨缺損、骨壞死不僅可以持續(xù)、高效地于局部釋放生長(zhǎng)因子,而且其提供的內(nèi)源性成骨生長(zhǎng)因子較外源性生長(zhǎng)因子具備更高的生物活性。慢病毒載體具有轉(zhuǎn)染效率高、可持續(xù)穩(wěn)定表達(dá)外源基因、增加調(diào)控基因后可調(diào)控目的蛋白的表達(dá)量、容納大片段的外源性目的基因和安全性高等優(yōu)點(diǎn)。將慢病毒介導(dǎo)的基因治療手段應(yīng)用到骨缺損治療中具有較傳統(tǒng)治療方法無可比擬的優(yōu)勢(shì)和廣闊的應(yīng)用前景。本文就慢病毒載體應(yīng)用在骨缺損基因治療中的研究進(jìn)展作一綜述。
[Abstract]:In the treatment of bone defect by genetic engineering, osteonecrosis can not only release growth factor locally, but also provide endogenous osteogenic growth factor with higher biological activity than exogenous growth factor. Lentivirus vector has the advantages of high transfection efficiency, sustained and stable expression of exogenous gene, increased expression of target protein after regulation gene, and high safety of accommodating large fragment of exogenous target gene. The application of lentivirus-mediated gene therapy in bone defect treatment has unparalleled advantages and broad application prospects. This article reviews the application of lentivirus vector in gene therapy of bone defect.
【作者單位】： 廣西醫(yī)科大學(xué)附屬口腔醫(yī)院口腔頜面外科;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(編號(hào):81360166、81160132) 廣西醫(yī)療衛(wèi)生重點(diǎn)科研課題資助項(xiàng)目(編號(hào):桂衛(wèi)重2011033)
【分類號(hào)】：R782.2
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本文編號(hào)：1890766