本文關(guān)鍵詞： 皰疹病毒 侵襲性牙周炎 Meta分析　出處：《山東大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：.研究證實(shí)皰疹病毒的檢出率與侵襲性牙周炎的發(fā)病及嚴(yán)重程度有關(guān)系,然而由于檢測(cè)人群、取樣方法以及檢測(cè)方法的差異,此種聯(lián)系仍然存在爭(zhēng)議。本課題擬通過(guò)總結(jié)現(xiàn)有的病例對(duì)照研究,探索皰疹病毒與侵襲性牙周炎之間的關(guān)系。方法：計(jì)算機(jī)檢索Pubmed、Embase、中國(guó)知網(wǎng)(CNKI)、萬(wàn)方數(shù)據(jù)知識(shí)服務(wù)平臺(tái)以及維普期刊資源整合服務(wù)平臺(tái),全面系統(tǒng)的收集對(duì)比皰疹病毒與侵襲性牙周炎關(guān)系的病例對(duì)照研究。檢索時(shí)間截止至2015年10月。按照Cochrane系統(tǒng)評(píng)價(jià)方法,2位評(píng)價(jià)者獨(dú)立使用納入標(biāo)準(zhǔn)篩選文獻(xiàn)、提取數(shù)據(jù)。運(yùn)用Revman及STATA軟件完成數(shù)據(jù)的綜合與處理。結(jié)果：與對(duì)照組相比,人巨細(xì)胞病毒(Human cytomegalovirus, HCMV)和單純皰疹病毒1型(Herpes simplex virus 1, HSV-1)均與侵襲性牙周炎顯示出明顯的相關(guān)性(HCMV共納入13項(xiàng)研究,p0.0001, OR= 5.37,95% CI=2.35-12.26; HSV-1共納入4項(xiàng)研究,p0.001, OR=20.99,95% CI=8.52-51.73),敏感性分析證實(shí)兩項(xiàng)結(jié)果穩(wěn)定可靠,Begg's等級(jí)相關(guān)測(cè)試(Begg's rank correlation test)及Egger's漏斗圖對(duì)稱性測(cè)試(Egger's funnel plot asymmetry test)證實(shí)無(wú)明顯的發(fā)表偏倚。EB病毒(Epstein-Barr virus, EBV)同樣顯示出與侵襲性牙周炎較高的相關(guān)性(共納入10項(xiàng)研究,p=0.001, OR=5.43,95% CI=1.94-15.22),敏感性分析證實(shí)結(jié)果穩(wěn)定,但是同時(shí)存在一定的發(fā)表偏倚。結(jié)論：綜合現(xiàn)有的研究證據(jù),HCMV和HSV-1的檢出率與侵襲性牙周炎顯示出明顯的相關(guān)性。
[Abstract]:Objective\\\. The relationship between herpesvirus and invasive periodontitis was explored by summarizing the existing case-control studies. Methods: Pubmeda Embase was searched by computer. CNKI, Wanfang data knowledge Service platform and Weipu periodical Resource Integration Service platform. A comprehensive and systematic case-control study was conducted to compare the relationship between herpes virus and invasive periodontitis. The search time was up to October 2015. According to the evaluation method of Cochrane system. Two evaluators independently used inclusion criteria to screen literature and extract data. Revman and STATA software were used to complete the data synthesis and processing. Results: compared with the control group. Human cytomegalovirus (simplex) and herpes simplex virus type 1 (Herpes simplex virus 1). HSV-1) showed significant correlation with invasive periodontitis. HCMV was included in 13 studies (P 0.0001, OR = 5.37). 95% CI 2.35-12.26; HSV-1 included 4 studies (p 0.001), ORG 20.99% CI 8.52-51.73. Sensitivity analysis confirmed that the two results were stable and reliable. Begg's grade correlation test (Beggs rank correlation test) and Egger's funnel symmetry test (. Egger's funnel plot asymmetry test confirmed that there was no obvious publication bias. Epstein-Barr virus. EBV also showed a high correlation with invasive periodontitis (including 10 studies, p0.001, ORV 5.43 95% CI 1.94-15.22). Sensitivity analysis confirmed that the results were stable, but there was a certain degree of publication bias. Conclusion: the detection rate of HCMV and HSV-1 is significantly correlated with invasive periodontitis.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R781.42

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 蔣運(yùn)杰;劉曉紅;田淑梅;;侵襲性牙周炎的診治體會(huì)[J];吉林大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2008年03期

2 笪海芹;徐燕;;抗生素治療侵襲性牙周炎的臨床研究進(jìn)展[J];臨床口腔醫(yī)學(xué)雜志;2009年06期

3 閆永發(fā);王永蘭;;侵襲性牙周炎病因的研究進(jìn)展[J];現(xiàn)代口腔醫(yī)學(xué)雜志;2010年05期

4 張帆;曹桂芬;黃萍;侯海娟;;C-反應(yīng)蛋白+1059G/C單核苷酸多態(tài)性與侵襲性牙周炎的相關(guān)性研究[J];實(shí)用口腔醫(yī)學(xué)雜志;2011年01期

5 何苗;;侵襲性牙周炎的病因?qū)W分析及其研究進(jìn)展[J];中外醫(yī)療;2011年08期

6 陳慧云;孫微微;;侵襲性牙周炎患者血漿β-防御素-2的檢測(cè)及臨床意義[J];放射免疫學(xué)雜志;2011年03期

7 李t，

本文編號(hào)：1493859