【摘要】：目的:本研究通過(guò)對(duì)不同劑量膽堿酯酶抑制劑多奈哌齊治療血管性癡呆的隨機(jī)對(duì)照試驗(yàn)進(jìn)行Meta分析,評(píng)價(jià)多奈哌齊治療血管性癡呆的有效性和安全性,為其臨床應(yīng)用提供有效的循癥醫(yī)學(xué)證據(jù)。方法:計(jì)算機(jī)檢索中國(guó)學(xué)術(shù)期刊(CNKI)數(shù)據(jù)庫(kù)、維普中文數(shù)據(jù)庫(kù)、萬(wàn)方數(shù)據(jù)庫(kù)、Pubmed、Cochrane Library、Embase等數(shù)據(jù)庫(kù)中有關(guān)多奈哌齊治療血管性癡呆的隨機(jī)對(duì)照試驗(yàn)。依據(jù)納入排除標(biāo)準(zhǔn)收集文獻(xiàn)。對(duì)收集的669篇文章進(jìn)行篩選,最終納入8篇符合條件的文獻(xiàn),提取相關(guān)數(shù)據(jù),采用Revman5.3軟件進(jìn)行統(tǒng)計(jì)分析,評(píng)價(jià)不同劑量多奈哌齊對(duì)血管性癡呆的療效及安全性。結(jié)果:多奈哌齊5mg/d組與多奈哌齊10mg/d組均較對(duì)照組治療血管性癡呆有明顯療效,可明顯提高簡(jiǎn)易智力狀態(tài)檢查量表(MMSE)的分值,且無(wú)劑量相關(guān)性。統(tǒng)計(jì)學(xué)分析結(jié)果為多奈哌齊5mg/d組與對(duì)照組:I2=21%,WMD=0.74,95%CI(0.44,1.05);多奈哌齊10mg/d與對(duì)照組:I2=0%,WMD=1.10,95%CI(0.58,1.62);多奈哌齊10mg/d組與多奈哌齊5mg/d組:I2=0%,WMD=0.29,95%CI(-0.05,0.64)。結(jié)論:根據(jù)此系統(tǒng)評(píng)價(jià)結(jié)果,5mg、10mg多奈哌齊對(duì)血管性癡呆患者認(rèn)知功能均有顯著改善作用,療效無(wú)明顯劑量相關(guān)性。
[Abstract]:Objective: to evaluate the efficacy and safety of Donepezil in the treatment of vascular dementia by Meta analysis in a randomized controlled trial of different doses of Donepezil, a cholinesterase inhibitor, in the treatment of vascular dementia. To provide effective medical evidence for its clinical application. Methods: the randomized controlled trials of Donepezil in the treatment of vascular dementia were searched by computer in the databases of Chinese academic journal (CNKI), Wip Chinese database, Wanfang database, Pubmed,Cochrane Library,Embase and so on. Collect documents according to the exclusion criteria. Six hundred and sixty-nine articles were selected and 8 articles were selected. The data were extracted and analyzed statistically with Revman5.3 software to evaluate the efficacy and safety of different doses of Donepezil in the treatment of vascular dementia. Results: Donepezil 5mg/d group and Donipezil 10mg/d group were more effective in treating vascular dementia than those in control group. The scores of (MMSE) in mini mental state examination scale were significantly increased, and there was no dose correlation between the two groups. The results of statistical analysis showed that the 5mg/d group and the control group were I2, WMD, 0.74, 95% CI (0.44, 1.05), and the 10mg/d and the control group were I 2? 0%, WMD? 1.10, 95% CI (0.58, 1.62). 10mg/d group and 5mg/d group: I2%, WMD 0.29,95% CI (- 0.05,0.64). Conclusion: according to the results of this systematic evaluation, 5mg and 10mg Donepezil could significantly improve cognitive function in patients with vascular dementia, and there was no significant dose correlation between the therapeutic effect and the cognitive function of the patients with vascular dementia.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R749.13

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 劉淑玲;施月仙;婁青;紀(jì)勇;;不同劑量多奈哌齊治療血管性認(rèn)知障礙的Meta分析[J];山東醫(yī)藥;2013年42期

2 王愛(ài)華;;高壓氧治療血管性癡呆癥的療效觀察[J];中國(guó)實(shí)用醫(yī)藥;2013年20期

3 孫賢楨;郭志男;;血管性癡呆的診斷及治療進(jìn)展[J];中國(guó)當(dāng)代醫(yī)藥;2012年31期

4 郝文莉;;鹽酸多奈哌齊治療血管性癡呆33例臨床療效觀察[J];中國(guó)現(xiàn)代藥物應(yīng)用;2010年08期

5 何小花;王雪峰;曾學(xué)清;王瑛;呂紅梅;;綜合康復(fù)治療血管性癡呆的臨床觀察[J];齊齊哈爾醫(yī)學(xué)院學(xué)報(bào);2009年20期

6 李中明;徐沙麗;李哈妮;;鹽酸多奈哌齊治療血管性癡呆33例[J];醫(yī)藥導(dǎo)報(bào);2008年10期

7 王彥;石文健;郝立科;紀(jì)茹英;;鹽酸多奈哌齊治療血管性癡呆臨床觀察[J];中國(guó)藥房;2006年18期

8 黎紅;何明大;黃旖旎;;腦心通膠囊對(duì)血管性癡呆模型大鼠海馬神經(jīng)細(xì)胞靜息態(tài)[Ca~(2+)]i的影響[J];中藥藥理與臨床;2006年Z1期

9 張秀清,顧愛(ài)霞,朱日華;血管性癡呆的危險(xiǎn)因素及防治進(jìn)展[J];現(xiàn)代康復(fù);2001年09期

10 賈建平;血管性癡呆的診斷和治療新進(jìn)展[J];引進(jìn)國(guó)外醫(yī)藥技術(shù)與設(shè)備;1999年12期

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