【摘要】：目的了解孤獨(dú)癥兒童血清中腦源性神經(jīng)營(yíng)養(yǎng)因子(brain-derived neurotrophic factor,BDNF)的水平及其與孤獨(dú)癥病情的關(guān)系。方法依據(jù)《精神疾病診斷與統(tǒng)計(jì)手冊(cè)-第4版(DSM-Ⅳ)》選擇已明確診斷的孤獨(dú)癥兒童53例,并按照兒童期孤獨(dú)癥評(píng)定量表(the children autism rating scale,CARS)標(biāo)準(zhǔn)對(duì)孤獨(dú)癥兒童進(jìn)行病情分級(jí);另選59例健康兒童作為對(duì)照。采用酶聯(lián)免疫吸附測(cè)定法(enzyme-linked immunosorbent assay,ELISA)檢測(cè)所有受試兒童血清中BDNF水平。采用SPSS 20.0統(tǒng)計(jì)軟件做兩組樣本t檢驗(yàn)進(jìn)行統(tǒng)計(jì)分析。結(jié)果孤獨(dú)癥兒童血清BDNF水平為(28.49±11.01)pg/ml,對(duì)照組兒童血清BDNF水平為(21.32±11.12)pg/ml,經(jīng)統(tǒng)計(jì)學(xué)分析顯示差異有統(tǒng)計(jì)學(xué)意義(t=3.42,P=0.001)。輕度孤獨(dú)癥兒童血清BDNF水平高于對(duì)照兒童(t=3.11,P=0.002),重度孤獨(dú)癥兒童血清BDNF水平與對(duì)照組兒童相比有增高趨勢(shì),但差異無(wú)統(tǒng)計(jì)學(xué)意義(t=1.49,P=0.142),輕度孤獨(dú)癥與重度孤獨(dú)癥兒童之間的BDNF水平差異無(wú)統(tǒng)計(jì)學(xué)意義(t=1.20,P=0.237)。孤獨(dú)癥患兒男性和女性之間BDNF水平差異無(wú)統(tǒng)計(jì)學(xué)意義(t=0.19,P=0.847)。結(jié)論孤獨(dú)癥兒童血清中BDNF水平高于對(duì)照組兒童,其中輕度孤獨(dú)癥兒童高于對(duì)照兒童,而重度孤獨(dú)癥兒童與對(duì)照兒童間差異無(wú)統(tǒng)計(jì)學(xué)意義。提示BDNF可能是孤獨(dú)癥患病風(fēng)險(xiǎn)的保護(hù)因素。
[Abstract]:Objective to investigate the level of brain-derived neurotrophic factor (brain-derived neurotrophic factor,BDNF) in serum of autistic children and its relationship with the condition of autism. Methods according to the Manual of diagnosis and Statistics of Mental Disorders-fourth Edition (DSM- 鈪，

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