【摘要】：目的探討重復(fù)經(jīng)顱磁刺激(repetitive transcranial magnetic stimulation,rTMS)聯(lián)合改良型無抽搐電休克治療(modified electroconvulsive therapy,MECT)及單純MECT治療對抑郁癥患者的療效及其對記憶功能的影響。方法將120例抑郁癥患者按隨機(jī)、雙盲的原則分成聯(lián)合治療組(實(shí)施rTMS聯(lián)合MECT治療)和單純MECT治療組(實(shí)施MECT治療和rTMS偽刺激),每組60例。療效評定采用漢密爾頓抑郁量表(HAMD),記憶功能評定采用修訂韋氏記憶測驗(yàn)(WMS-RC)、行為記憶測驗(yàn)第2版(RBMTⅡ),3個量表分別于第1次MECT治療開始前及第24次rTMS或偽刺激結(jié)束后的治療終點(diǎn)進(jìn)行評定。結(jié)果兩組治療終點(diǎn)的HAMD評分較治療前均明顯下降(P0.05),聯(lián)合治療組治療終點(diǎn)評分較單純MECT治療組明顯降低(P0.05);兩組治療終點(diǎn)WMS-RC評分中積累、背數(shù)、圖片、再認(rèn)、理解和聯(lián)想評分均較治療前明顯降低(P0.05),聯(lián)合治療組治療終點(diǎn)評分高于單純MECT治療組(P0.05);兩組治療終點(diǎn)RBMTⅡ評分中回憶姓名、回憶被藏物品、圖片再認(rèn)、故事即刻回憶、故事延遲回憶、臉部再認(rèn)、路線即刻回憶、路線延遲回憶、信件即刻回憶、信件延遲回憶評分均較治療前明顯降低(P0.05),聯(lián)合治療組治療終點(diǎn)評分高于單純治療組(P0.05)。結(jié)論 rTMS聯(lián)合MECT治療與單純MECT治療療效相當(dāng),但對抑郁癥患者記憶功能影響比單純MECT治療小。
[Abstract]:Objective to investigate the effect of repeated transcranial magnetic stimulation (repetitive transcranial magnetic stimulation,rTMS) combined with modified non-convulsive electroconvulsive therapy (modified electroconvulsive therapy,MECT) and MECT alone on depression and its effect on memory function. Methods one hundred and twenty patients with depression were randomly divided into two groups: the combined treatment group (rTMS combined with MECT) and the simple MECT group (MECT treatment and rTMS pseudo-stimulation). There were 60 cases in each group. The therapeutic effect was evaluated by Hamilton Depression scale (HAMD),) and modified Wechsler memory Test (WMS-RC) and Behavioral memory Test (RBMT 鈪，

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