從譫妄的血清生物標志物探討譫妄發(fā)生機制
發(fā)布時間：2018-12-25 14:59
【摘要】：譫妄是由多種影響因素引起大腦皮質(zhì)功能障礙而發(fā)生的急性認知功能紊亂。目前關(guān)于譫妄病理生理機制的基礎(chǔ)研究較少。譫妄生物標志物的研究有助于闡明其病理生理機制,且對其診斷、嚴重程度分級及遠期結(jié)局預測有著重要意義。本文回顧了譫妄相關(guān)的三類血清生物標志物的研究進展:(1)風險標志物:譫妄發(fā)作前在血清中出現(xiàn)或增高表達,包括血清化學物、基因標志物等。(2)活性標志物:譫妄發(fā)生時增高表達,恢復時表達水平降低,包括乙酰膽堿、血清抗膽堿能活性、5-羥色胺、血清氨基酸、褪黑素、白細胞介素和C-反應(yīng)蛋白等炎癥標志物。(3)終產(chǎn)物:根據(jù)疾病的嚴重程度或結(jié)局呈比例升高,包括S-100?、神經(jīng)元特異性烯醇酶等。以上三類標志物有助于我們進一步探討譫妄的發(fā)生機制。
[Abstract]:Delirium is an acute cognitive disorder caused by multiple factors affecting cerebral cortex dysfunction. At present, there are few basic researches on the pathophysiological mechanism of delirium. The study of biomarkers of delirium is helpful to elucidate the pathophysiological mechanism of delirium and play an important role in the diagnosis, severity classification and long term outcome prediction. This paper reviews the research progress of three serum biomarkers associated with delirium: (1) risk markers: the presence or elevation of serum biomarkers, including serum chemicals, prior to the onset of delirium. (2) activity markers: increased expression at the onset of delirium and decreased expression at recovery, including acetylcholine, serum anticholinergic activity, serotonin, serum amino acid, melatonin, Inflammatory markers such as interleukin and C-reactive protein. (3) Endproduct: according to the severity or outcome of the disease increased proportionally, including S-100, neuron-specific enolase and so on. The above three kinds of markers are helpful to further study the pathogenesis of delirium.
【作者單位】： 四川大學華西醫(yī)院國家老年疾病臨床醫(yī)學研究中心;四川大學華西醫(yī)院老年醫(yī)學中心;
【基金】：米爾斯坦基金(H1403014)
【分類號】：R749.1
本文編號：2391283
[Abstract]:Delirium is an acute cognitive disorder caused by multiple factors affecting cerebral cortex dysfunction. At present, there are few basic researches on the pathophysiological mechanism of delirium. The study of biomarkers of delirium is helpful to elucidate the pathophysiological mechanism of delirium and play an important role in the diagnosis, severity classification and long term outcome prediction. This paper reviews the research progress of three serum biomarkers associated with delirium: (1) risk markers: the presence or elevation of serum biomarkers, including serum chemicals, prior to the onset of delirium. (2) activity markers: increased expression at the onset of delirium and decreased expression at recovery, including acetylcholine, serum anticholinergic activity, serotonin, serum amino acid, melatonin, Inflammatory markers such as interleukin and C-reactive protein. (3) Endproduct: according to the severity or outcome of the disease increased proportionally, including S-100, neuron-specific enolase and so on. The above three kinds of markers are helpful to further study the pathogenesis of delirium.
【作者單位】： 四川大學華西醫(yī)院國家老年疾病臨床醫(yī)學研究中心;四川大學華西醫(yī)院老年醫(yī)學中心;
【基金】：米爾斯坦基金(H1403014)
【分類號】：R749.1
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