【摘要】：目的：比較抗抑郁劑單藥與聯(lián)合使用非典型抗精神病藥物治療驚恐障礙的療效及衛(wèi)生經(jīng)濟學指標，為今后制定合理的治療方案，降低醫(yī)療費用提供參考依據(jù)。 方法：回顧性分析98例首次住院確診的驚恐障礙患者的臨床資料，，其中單獨使用抗抑郁劑組（單藥組）43例，聯(lián)合使用非典型抗精神病藥物（聯(lián)合組）55例，兩組患者均進行漢密頓焦慮量表（HAMA）、漢密頓抑郁量表（HAMD）評分。比較兩組的治愈率、有效率、HAMA總分及各因子分、HAMD總分及各因子分、住院天數(shù)、住院費用等。 結果： （1）單藥組治愈率為67.4%，有效率97.7%，聯(lián)合用藥組治愈為63.6%，有效率98.2%，兩組比較差異均無統(tǒng)計學意義（P＞0.05）。 （2）兩組患者治療后HAMA總分、軀體化焦慮因子分及精神性焦慮因子分比較，差異均無統(tǒng)計學意義（P＞0.05）。 （3）兩組患者治療后阻滯因子分比較，差異有統(tǒng)計學意義（P＜0.05）；但HAMD總分、焦慮/軀體化因子分、體重因子分、認識障礙因子分、睡眠障礙因子分、絕望感因子分及全身癥狀因子分比較，差異均無統(tǒng)計學意義（P＞0.05）。 （4）兩組住院天數(shù)比較差異無統(tǒng)計學意義（P＞0.05），但聯(lián)合組住院費用高于單藥組（P＜0.05）。 結論：聯(lián)合使用非典型抗精神病藥物和單藥治療驚恐障礙，療效無明顯差異，患者住院天數(shù)未能減少，反而增加了住院費用。
[Abstract]:Objective: to compare the efficacy of antidepressant alone and atypical antipsychotics in the treatment of panic disorder and to provide reference basis for formulating reasonable treatment plan and reducing medical cost in the future. Methods: the clinical data of 98 patients with panic disorder diagnosed for the first time in hospital were retrospectively analyzed. There were 43 patients in the single antidepressant group and 55 in the combined group who were treated with atypical antipsychotics. Hamilton anxiety scale (HAMA),) and Hamilton Depression scale (HAMD) were used in both groups. The cure rate, effective rate, HAMA total score and each factor score, HAMD total score and each factor score, hospitalization days, hospitalization expenses and so on were compared between the two groups. Results: (1) the cure rate was 67.4 and the effective rate was 97.7in the single drug group, the cure rate was 63.6 in the combined group and the effective rate was 98.2. There was no significant difference between the two groups (P > 0.05). (2) there was no significant difference in the total score of HAMA, the score of somatization anxiety factor and the score of mental anxiety factor between the two groups after treatment (P > 0. 05). (3) there was significant difference in the scores of block factors between the two groups after treatment (P < 0.05). However, there was no significant difference in total HAMD score, anxiety / somatization factor score, body weight factor score, cognition disorder factor score, sleep disturbance factor score, despair factor score and systemic symptom factor score (P > 0. 05). (4) there was no significant difference in hospitalization days between the two groups (P > 0.05), but the cost of hospitalization in the combined group was higher than that in the single drug group (P < 0.05). Conclusion: the combination of atypical antipsychotics and single drug in the treatment of panic disorder has no significant difference in curative effect, and the hospitalization days of the patients are not reduced, but the hospitalization costs are increased.
【學位授予單位】：廣西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R749.7

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