本文選題：認(rèn)知損害 + 老年性癡呆　； 參考：《華中科技大學(xué)》2012年碩士論文

【摘要】：目的：探討全科醫(yī)生認(rèn)知評(píng)估量表GPCOG的中文譯本在中國社區(qū)認(rèn)知篩查中的應(yīng)用價(jià)值，為基層臨床醫(yī)生及社區(qū)全科醫(yī)生尋找一個(gè)簡短高效、便于操作、依從性好的認(rèn)知障礙篩查工具。 方法：所有的調(diào)查對(duì)象采用中文版GPCOG和MMSE進(jìn)行認(rèn)知功能調(diào)查，其中部分受試者于一周后復(fù)查GPCOG檢測(cè)重測(cè)信度。采用精神疾病診斷與統(tǒng)計(jì)手冊(cè)DSM-IV標(biāo)準(zhǔn)[1-2]建立可能老年性癡呆診斷，通過信度、效度和ROC曲線、AUC、約登指數(shù)等指標(biāo)評(píng)價(jià)GPCOG中文譯本在社區(qū)老年人認(rèn)知篩查中的應(yīng)用價(jià)值。 結(jié)果：共計(jì)297人符合入組標(biāo)準(zhǔn)并完成本次調(diào)查，平均年齡71.43±9.80歲，檢出老年性癡呆患者43人，總檢出率14.48%。本研究顯示年齡、教育程度與老年性癡呆發(fā)病率顯著相關(guān)（P＜0.01），性別間則無顯著差異。本GPCOG中文版Cronbach'sα為0.775，各項(xiàng)目間及與總分間相關(guān)系數(shù)在0.472~0.929（P＜0.05）之間，僅時(shí)間定向與其他各項(xiàng)、總分相關(guān)性稍低（0.298~0.503），，GPCOG患者檢測(cè)部分重測(cè)信度0.9498（P=0.000），以上數(shù)據(jù)均顯示出GPCOG具有良好的穩(wěn)定性和一致性。GPCOG篩查老年性癡呆的靈敏性為93.02%，特異性為84.65%，與MMSE總分經(jīng)SPearman相關(guān)性檢驗(yàn)呈顯著相關(guān)（r=0.761，P=0.000），患者測(cè)試部分ROC曲線下面積（AUC）為0.926（標(biāo)準(zhǔn)誤=0.017，P=0.000），總分ROC曲線下面積（AUC）為0.933（標(biāo)準(zhǔn)誤=0.016，P=0.000），以上數(shù)據(jù)表明GPCOG效度較好。結(jié)論：GPCOG具有較好的信度和效度，敏感性高，是一種適用于基層全科醫(yī) 生的簡短高效、便于操作、依從性好的認(rèn)知障礙篩查工具。
[Abstract]:Objective: To explore the application value of the Chinese version of the general practitioner cognitive assessment scale (GPCOG) in Chinese community cognitive screening, and to find a short, efficient, convenient and compliant cognitive barrier screening tool for clinicians and community general practitioners at the grass-roots level.
Methods: all subjects were investigated using the Chinese version of GPCOG and MMSE to investigate the cognitive function. Some of the subjects reviewed the GPCOG test reliability one week later. The diagnosis of Alzheimer's disease was established by the DSM-IV standard [1-2] of mental disease diagnosis and statistics, and the reliability, validity and ROC curve, AUC, and the Jordan index index were used to evaluate G. The application value of PCOG Chinese version in the cognitive screening of the elderly in the community.
Results: a total of 297 people were in accordance with the standard of entry group and completed the survey. The average age was 71.43 + 9.80 years old. 43 people with Alzheimer's disease were detected. The total detection rate was 14.48%.. This study showed that the education level was significantly related to the incidence of Alzheimer's disease (P < 0.01), and there was no significant difference between the sexes. The Chinese version of the Chinese version of GPCOG was 0.775. The correlation coefficient between the total and the total scores was between 0.472~0.929 (P < 0.05), only time orientation and other items, the correlation of total score was slightly lower (0.298~0.503), and the reliability of GPCOG patients was 0.9498 (P=0.000). The above data showed that GPCOG had good stability and consistency, and the sensitivity of.GPCOG screening for Alzheimer's disease was 93.02%, and the specificity was 93.02%. The sex was 84.65%, and the total score of MMSE was significantly correlated with the SPearman correlation test (r=0.761, P=0.000). The area under the ROC curve (AUC) was 0.926 (standard false =0.017, P=0.000), and the area under the total ROC curve (AUC) was 0.933 (standard error =0.016, P=0.000). Validity and high sensitivity are suitable for general practitioners at the basic level.
Students are short, efficient, easy to operate, and have good compliance with cognitive impairment screening tools.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R749.2

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