本文選題：神經(jīng)心理學 + 神經(jīng)生長因子　； 參考：《安徽醫(yī)科大學》2013年碩士論文

【摘要】：據(jù)報道全世界每年有約10萬人死于吸毒，我國目前登記在冊的吸毒人員有100萬左右。嗎啡、海洛因等毒品被人們反復使用后，會產生軀體依賴性和精神依賴性，軀體依賴性主要表現(xiàn)為戒斷癥狀，精神依賴性則是藥物對中樞神經(jīng)系統(tǒng)作用后所產生的一種特殊的獎賞效應，表現(xiàn)為心理渴求和持續(xù)精神焦慮、抑郁障礙；而精神依賴性是導致復吸的重要原因，同時持續(xù)心理渴求、精神抑郁障礙又嚴重影響吸毒者的心理健康和人格健全。 海洛因依賴者脫毒期抑郁癥屬于藥物引發(fā)的繼發(fā)性抑郁障礙，但目前大多數(shù)治療方法仍然采用抗抑郁藥物為主的治療方法，另外也有采用心理認知療法、中醫(yī)中藥等，雖然一定程度上在緩解海洛因依賴者脫毒期抑郁及心理渴求癥狀，但療效反復，，臨床治愈率低。 本研究采用神經(jīng)生長因子(nerve growth factor NGF）聯(lián)合西酞普蘭的治療方式,從神經(jīng)心理學角度積極探索治療海洛因依賴者脫毒期抑郁癥的有效方法，分析其心理渴求、抑郁癥狀的可能發(fā)病原因和發(fā)病機制，并為今后的戒毒治療提供參考。 目的： 評價神經(jīng)生長因子聯(lián)合西酞普蘭對海洛因依賴者的抑郁及心理渴求癥狀的治療效果。 方法： 將93名男性患者隨機分為兩組，其中西酞普蘭治療組41人，神經(jīng)生長因子(NGF）聯(lián)合西酞普蘭治療組42人，治療前兩組罪犯的年齡、刑期及Beck抑郁自評問卷(BDI-13)評分比較均無統(tǒng)計學差異。除戒毒用藥美沙酮及丁丙諾啡外，兩組分別應用西酞普蘭和神經(jīng)生長因子聯(lián)合西酞普蘭進行治療，療程為6周。采用Beck抑郁自評問卷(BDI-13)、心理渴求自評量表及臨床療效總評量表(CGI)進行評定療效。 結果： 神經(jīng)生長因子聯(lián)合西酞普蘭組治療后1、2、4、6周末BDI-13評分及減分率較西酞普蘭組有明顯差異(P0.05)；神經(jīng)生長因子聯(lián)合西酞普蘭組治療后14、21、28、35、42天末心理渴求評分較西酞普蘭組明顯下降(P0.05)：神經(jīng)生長因子聯(lián)合西酞普蘭組治療后1、2、4、6周末臨床療效總評量表(CGI)評分較西酞普蘭組明顯減少(P0.05)。 結論： 神經(jīng)生長因子聯(lián)合西酞普蘭可有效地減輕海洛因依賴者在脫毒期抑郁及心理渴求癥狀。
[Abstract]:It is reported that about 100000 people die from drug abuse every year in the world, and about 1 million drug addicts are registered in our country. After repeated use of morphine, heroin and other drugs, they will produce physical and mental dependence, which is mainly manifested as withdrawal symptoms. Mental dependence is a special reward effect after the effect of drugs on the central nervous system, which is manifested by psychological craving, persistent mental anxiety and depression, and mental dependence is an important cause of relapse. At the same time, persistent psychological craving and mental depression seriously affect the mental health and personality of drug addicts. Detoxifying detoxification of heroin addicts is a secondary depressive disorder caused by drugs. However, at present, most of the treatment methods still use antidepressants as the main treatment methods, in addition, they also use psychological cognitive therapy, traditional Chinese medicine, and so on. Although the depressive and psychological craving symptoms in detoxified heroin addicts were alleviated to some extent, the curative effect was repeated and the clinical cure rate was low. In this study, nerve growth factor combined with citalopram was used to explore the effective treatment of detoxified depression in heroin addicts from the perspective of neuropsychology, and to analyze their psychological craving. The possible causes and pathogenesis of depressive symptoms, and provide reference for the future treatment of detoxification. Aim: to evaluate the effect of nerve growth factor (NGF) combined with citalopram on depression and craving symptoms in heroin addicts. Methods: 93 male patients were randomly divided into two groups: 41 in citalopram group and 42 in NGF combined with citalopram group. There was no significant difference in prison term and BDI-13 score in Beck self-assessment depression questionnaire. In addition to methadone and buprenorphine, the two groups were treated with citalopram and nerve growth factor combined with citalopram for 6 weeks. The efficacy was evaluated by Beck self-rating depression questionnaire BDI-13 psychological craving scale and General efficacy scale (CGI). Results: the BDI-13 score and score reduction rate of NGF combined with citalopram group were significantly different from those of citalopram group at the end of 6 weeks. The scores of craving at the end of 42 days in the NGF combined with citalopram group were significantly lower than those in the citalopram group at the end of 42 days. The CGI scores of NGF combined with citalopram group at the end of the week were higher than those in the citalopram group at the end of the week. In the group of Plain, the concentration of P0. 05 was significantly decreased. Conclusion: NGF combined with citalopram can effectively relieve detoxification depression and craving symptoms in heroin addicts.
【學位授予單位】：安徽醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R749.6

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